SCN4B

SCN4B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4MZ2, 4MZ3
Identifikatori
Aliasi	SCN4B
Vanjski ID-jevi	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	118,152,888 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	45,065,450 bp
Ontologija gena
Molekularna funkcija	• sodium channel regulator activity; • transmembrane transporter binding; • sodium channel activity; • voltage-gated ion channel activity; • voltage-gated sodium channel activity involved in cardiac muscle cell action potential; • voltage-gated sodium channel activity;
Ćelijska komponenta	• voltage-gated sodium channel complex; • integral component of membrane; • membrana; • Interkalirani disk; • intrinsic component of plasma membrane; • ćelijska membrana;
Biološki proces	• cardiac muscle contraction; • sodium ion transmembrane transport; • sodium ion transport; • regulation of ion transmembrane transport; • cardiac muscle cell action potential involved in contraction; • ion transport; • regulation of sodium ion transmembrane transporter activity; • GO:0061423 positive regulation of sodium ion transport; • AV node cell action potential; • regulation of heart rate by cardiac conduction; • membrane depolarization during cardiac muscle cell action potential; • regulation of ventricular cardiac muscle cell membrane repolarization;
	Izvori:Amigo / QuickGO
Ortolozi
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

β-podjedinica 4 natrijevog kanala, znana i kao SCN4B ili Naβ4, i pomoćna je podjedinica natrijskih kanala koja može promijeniti njihovu kinetiku. To jest protein koji je kod ljudi kodiran genom SCN4B sa hromosoma 11.^[5]^[6] Mutacije u SCN4B povezane su sa sindromom dugog QT intervala.^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 228 aminokiselina, a molekulska masa 24.969 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPGAGDGGKA	PARWLGTGLL	GLFLLPVTLS	LEVSVGKATD	IYAVNGTEIL
LPCTFSSCFG	FEDLHFRWTY	NSSDAFKILI	EGTVKNEKSD	PKVTLKDDDR
ITLVGSTKEK	MNNISIVLRD	LEFSDTGKYT	CHVKNPKENN	LQHHATIFLQ
VVDRLEEVDN	TVTLIILAVV	GGVIGLLILI	LLIKKLIIFI	LKKTREKKKE
CLVSSSGNDN	TENGLPGSKA	EEKPPSKV

Funkcija[uredi | uredi izvor]

SCN4B might additionally function as a cell adhesion molecule.^[8]^[9]

Također pogledajte[uredi | uredi izvor]

Natrijski kanal

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology (jezik: engleski). 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
^ ^a ^b "Entrez Gene: sodium channel".
^ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
^ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
^ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

Dopunska literatura[uredi | uredi izvor]

Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. doi:10.1523/JNEUROSCI.23-20-07577.2003. PMC 6740763. PMID 12930796.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

Vanjski linkovi[uredi | uredi izvor]

Q8IWT1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology (jezik: engleski). 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.

[entrez-6] "Entrez Gene: sodium channel".

[pmid17592081-7] Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

[pmid27216889-8] Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

[pmid28655765-9] Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

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