SERF2

SERF2
Identifikatori
Aliasi	SERF2
Vanjski ID-jevi	OMIM: 605054 MGI: 1337041 HomoloGene: 85994 GeneCards: SERF2
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	43,804,427 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	121,288,794 bp
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• citosol; • jedro;
Biološki proces	• GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	10169
	378702
	ENSG00000140264
	ENSMUSG00000074884
	P84101
	P84102
NM_001018108; NM_001199875; NM_001199876; NM_001199877; NM_001199878;
	NM_005770
	NM_001290837; NM_011354
	NP_001018118; NP_001186804; NP_001186805; NP_001186806; NP_001186807
	NP_001277766; NP_035484
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mali EDRK-bogati faktor 2 je protein koji je kod ljudi kodiran genom SERF2.^[5]^[6]

Gross (2014) mapirao je gen SERF2 na hromosomu 15q15.3, na osnovu poravnanja sekvence SERF2 (GenBank AF073298) sa genomskom sekvencom (GRCh37).^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 59 aminokiselina, a molekulska težina 6.900 Da.^[8].

10		20		30		40		50
MTRGNQRELA		RQKNMKKQSD		SVKGKRRDDG		LSAAARKQRD		SEIMQQKQKK
ANEKKEEPK

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Kloniranje i ekspresija

Koristeći komparativnu genomiku, sekvenciranje BAC koji sadrži Smn miša i pretraživanje baze podataka EST, praćeno PCR bibliotekom cDNK mozga miša i ljudskog skeletnih mišića, Scharf et al. (1998) izolirali su cDNK koje kodiraju H4F5 (SERF1) i H4F5REL (SERF2). Analizom sekvence utvrđeno je da SERF2 kodira izvedeni 59-aminokiselinski protein koji ima 69% aminokiselinskog identiteta sa SERF1. SERF2 je visoko nabijeni heliks-okret-heliks protein sa 33% ostataka ili lys ili arg, što sugerira ulogu u vezivanju nukleinskih kiselina.^[9]

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000140264 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074884 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Scharf JM, Endrizzi MG, Wetter A, Huang S, Thompson TG, Zerres K, Dietrich WF, Wirth B, Kunkel LM (septembar 1998). "Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics". Nature Genetics. 20 (1): 83–6. doi:10.1038/1753. PMID 9731538.
↑ "Entrez Gene: SERF2 small EDRK-rich factor 2".
↑ Gross, M. B. Personal Communication. Baltimore, Md. 3/24/2014.
↑ "UniProt, P84101". Pristupljeno 18. 7. 2021.
↑ Scharf, J. M., Endrizzi, M. G., Wetter, A., Huang, S., Thompson, T. G., Zerres, K., Dietrich, W. F., Wirth, B., Kunkel, L. M. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Nature Genet. 20: 83-86, 1998. PubMed: 9731538

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (septembar 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (oktobar 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y (august 2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Molecular Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.

Vanjski linkovi

SERF2 lokacija ljudskog genoma UCSC Genome Browser.
Šablon:UCSC

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140264 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074884 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9731538-5] Scharf JM, Endrizzi MG, Wetter A, Huang S, Thompson TG, Zerres K, Dietrich WF, Wirth B, Kunkel LM (septembar 1998). "Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics". Nature Genetics. 20 (1): 83–6. doi:10.1038/1753. PMID 9731538.

[entrez-6] "Entrez Gene: SERF2 small EDRK-rich factor 2".

[7] Gross, M. B. Personal Communication. Baltimore, Md. 3/24/2014.

[UniProt-8] "UniProt, P84101". Pristupljeno 18. 7. 2021.

[9] Scharf, J. M., Endrizzi, M. G., Wetter, A., Huang, S., Thompson, T. G., Zerres, K., Dietrich, W. F., Wirth, B., Kunkel, L. M. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Nature Genet. 20: 83-86, 1998. PubMed: 9731538

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