SGPL1

SGPL1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4Q6R
Identifikatori
Aliasi	SGPL1
Vanjski ID-jevi	OMIM: 603729 MGI: 1261415 HomoloGene: 2897 GeneCards: SGPL1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	70,881,184 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	60,983,482 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • catalytic activity; • lyase activity; • pyridoxal phosphate binding; • carboxy-lyase activity; • sphinganine-1-phosphate aldolase activity;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • membrana; • integral component of endoplasmic reticulum membrane; • Endoplazmatski retikulum;
Biološki proces	• fibroblast migration; • roof of mouth development; • luteinization; • Leydig cell differentiation; • estrogen metabolic process; • androgen metabolic process; • Nefrogeneza; • ceramide metabolic process; • regulation of multicellular organism growth; • lipid metabolism; • carboxylic acid metabolic process; • skeletal system morphogenesis; • sphingolipid biosynthetic process; • post-embryonic development; • fatty acid metabolic process; • female gonad development; • Vaskulogeneza; • nitrogen compound metabolic process; • Spermatogeneza; • apoptotic signaling pathway; • platelet-derived growth factor receptor signaling pathway; • face morphogenesis; • GO:0097285 apoptoza; • sphingolipid metabolic process; • sphingolipid catabolic process; • Hematopoeza; • ameboidal-type cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	8879
	20397
	ENSG00000166224
	ENSMUSG00000020097
	O95470
	Q8R0X7
	NM_003901
	NM_009163; NM_001316673; NM_001316674
	NP_003892
	NP_001303602; NP_001303603; NP_033189
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sfingozin-1-fosfat lijaza 1 je enzim koji je kod ljudi kodiran genom SGPL1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 568 aminokiselina, а molekulska težina 63.524 Da.^[8]

10	20	30	40	50
MPSTDLLMLK	AFEPYLEILE	VYSTKAKNYV	NGHCTKYEPW	QLIAWSVVWT
LLIVWGYEFV	FQPESLWSRF	KKKCFKLTRK	MPIIGRKIQD	KLNKTKDDIS
KNMSFLKVDK	EYVKALPSQG	LSSSAVLEKL	KEYSSMDAFW	QEGRASGTVY
SGEEKLTELL	VKAYGDFAWS	NPLHPDIFPG	LRKIEAEIVR	IACSLFNGGP
DSCGCVTSGG	TESILMACKA	YRDLAFEKGI	KTPEIVAPQS	AHAAFNKAAS
YFGMKIVRVP	LTKMMEVDVR	AMRRAISRNT	AMLVCSTPQF	PHGVIDPVPE
VAKLAVKYKI	PLHVDACLGG	FLIVFMEKAG	YPLEHPFDFR	VKGVTSISAD
THKYGYAPKG	SSLVLYSDKK	YRNYQFFVDT	DWQGGIYASP	TIAGSRPGGI
SAACWAALMH	FGENGYVEAT	KQIIKTARFL	KSELENIKGI	FVFGNPQLSV
IALGSRDFDI	YRLSNLMTAK	GWNLNQLQFP	PSIHFCITLL	HARKRVAIQF
LKDIRESVTQ	IMKNPKAKTT	GMGAIYGMAQ	TTVDRNMVAE	LSSVFLDSLY
STDTVTQGSQ	MNGSPKPH

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".
^ "UniProt, O95470". Pristupljeno 4. 9. 2021.

Dopunska literatuara[uredi | uredi izvor]

Van Veldhoven PP, Mannaerts GP (1991). "Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver". J. Biol. Chem. 266 (19): 12502–7. PMID 2061324.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Van Veldhoven PP, Gijsbers S, Mannaerts GP, et al. (2000). "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)". Biochim. Biophys. Acta. 1487 (2–3): 128–34. doi:10.1016/s1388-1981(00)00079-2. PMID 11018465.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reiss U, Oskouian B, Zhou J, et al. (2004). "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis". J. Biol. Chem. 279 (2): 1281–90. doi:10.1074/jbc.M309646200. PMID 14570870.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9464245-5] Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.

[pmid17090686-6] Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.

[entrez-7] "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

[UniProt-8] "UniProt, O95470". Pristupljeno 4. 9. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak