SLC8B1

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SLC8B1
Identifikatori
AliasiSLC8B1
Vanjski ID-jeviOMIM: 609841 MGI: 2180781 HomoloGene: 41602 GeneCards: SLC8B1
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za SLC8B1
Genomska lokacija za SLC8B1
Bend12q24.13Početak113,298,759 bp[1]
Kraj113,359,493 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za SLC8B1
Genomska lokacija za SLC8B1
Bend5|5 FPočetak120,649,233 bp[2]
Kraj120,672,089 bp[2]
Ontologija gena
Molekularna funkcija protein homodimerization activity
identical protein binding
antiporter activity
calcium:cation antiporter activity
calcium:sodium antiporter activity
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
Ćelijska komponenta integral component of membrane
membrana
Ćelijska membrana
Krista
mitohondrija
integral component of mitochondrial membrane
Sarkolema
mitochondrial inner membrane
Biološki proces sodium ion transmembrane transport
regulation of cytosolic calcium ion concentration
glucose homeostasis
response to stimulus
regulation of insulin secretion
sodium ion transport
ion transport
calcium ion transmembrane transport
regulation of cardiac muscle cell membrane potential
calcium ion transport
transmembrane transport
mitochondrial calcium ion transmembrane transport
mitochondrial calcium ion homeostasis
calcium export from the mitochondrion
regulation of lymphocyte chemotaxis
regulation of store-operated calcium entry
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_024959
NM_001330466
NM_001358345

NM_001177594
NM_001177595
NM_133221

RefSeq (bjelančevina)

NP_001317395
NP_079235
NP_001345274

NP_001171065
NP_001171066
NP_573484

Lokacija (UCSC)Chr 12: 113.3 – 113.36 MbChr 5: 120.65 – 120.67 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Član B1 porodice rastvornih nosača 8 (natrij/litij/kalcijski izmjenjivač exchanger) je protein koji je kod ljudi kodiran genom SLC8B1.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 584 aminokiselina, a molekulska težina 64.231 Da.[6]

Simboli
1020304050
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPV
VDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAV
TLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNG
APDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASR
PFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWI
YQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKD
DQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTA
LASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVV
FRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNIL
VGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCF
QLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM

Funkcija[uredi | uredi izvor]

SLC24A6 pripada porodici Kalij-ovisni izmjenjivač natrij-kalcij koji održavaju ćelijsku homeostazu kalcija, putem elektrogenog protivtransporta četiri iona natrija za jedan ion kalcija i jedan kalija.[7]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089060 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032754 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
  6. ^ "UniProt, Q6J4K2". Pristupljeno 14. 8. 2021.
  7. ^ Cai X, Lytton J (februar 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Dopunska literatura[uredi | uredi izvor]