SLCO4C1

SLCO4C1
Identifikatori
Aliasi	SLCO4C1
Vanjski ID-jevi	OMIM: 609013 MGI: 2442784 HomoloGene: 62654 GeneCards: SLCO4C1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	102,296,284 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	96,799,896 bp
Ontologija gena
Molekularna funkcija	• transporter activity; • sodium-independent organic anion transmembrane transporter activity;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • basolateral plasma membrane; • Egzosom; • membrana; • azurophil granule membrane; • specific granule membrane; • integral component of plasma membrane;
Biološki proces	• multicellular organism development; • Ćelijska diferencijacija; • ion transport; • Spermatogeneza; • neutrophil degranulation; • sodium-independent organic anion transport; • GO:0015915 transport; • transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	353189
	227394
	ENSG00000173930
	ENSMUSG00000040693
	Q6ZQN7
	Q8BGD4
	NM_180991
	NM_172658
	NP_851322
	NP_766246
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 4 porodice trasportera organskih aniona rastvornih nosača je protein koji je kod ljudi kodiran genom SLCO4C1sa hromosoma 5, sekcenca q21. OATP4C1 protein eksprimira se u bazolaterlnoj membrani nefrona ljudskog bubrega, gdje je uključen u preuzimanje organskih aniona radi eliminacije u mokraći. Lijek digoksin je važan supstrat ovog transportera.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 724 aminokiseline, a molekulska težina 78.948 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKSAKGIENL	AFVPSSPDIL	RRLSASPSQI	EVSALSSDPQ	RENSQPQELQ
KPQEPQKSPE	PSLPSAPPNV	SEEKLRSLSL	SEFEEGSYGW	RNFHPQCLQR
CNTPGGFLLH	YCLLAVTQGI	VVNGLVNISI	STVEKRYEMK	SSLTGLISSS
YDISFCLLSL	FVSFFGERGH	KPRWLAFAAF	MIGLGALVFS	LPQFFSGEYK
LGSLFEDTCV	TTRNSTSCTS	STSSLSNYLY	VFILGQLLLG	AGGTPLYTLG
TAFLDDSVPT	HKSSLYIGTG	YAMSILGPAI	GYVLGGQLLT	IYIDVAMGES
TDVTEDDPRW	LGAWWIGFLL	SWIFAWSLII	PFSCFPKHLP	GTAEIQAGKT
SQAHQSNSNA	DVKFGKSIKD	FPAALKNLMK	NAVFMCLVLS	TSSEALITTG
FATFLPKFIE	NQFGLTSSFA	ATLGGAVLIP	GAALGQILGG	FLVSKFRMTC
KNTMKFALFT	SGVALTLSFV	FMYAKCENEP	FAGVSESYNG	TGELGNLIAP
CNANCNCSRS	YYYPVCGDGV	QYFSPCFAGC	SNPVAHRKPK	VYYNCSCIER
KTEITSTAET	FGFEAKAGKC	ETHCAKLPIF	LCIFFIVIIF	TFMAGTPITV
SILRCVNHRQ	RSLALGIQFM	VLRLLGTIPG	PIIFGFTIDS	TCILWDINDC
GIKGACWIYD	NIKMAHMLVA	ISVTCKVITM	FFNGFAIFLY	KPPPSATDVS
FHKENAVVTN	VLAEQDLNKI	VKEG

Funkcija[uredi | uredi izvor]

SLCO4C1 pripada porodici transportera organskih aniona (OATP). OATP su uključeni u membranski transport žučnih kiselina, konjugiranih steroida, hormona štitnjače, eikozanoida, peptida i brojnih lijekova u mnogim tkivima (Mikkaichi et al., 2004 PubMed 14993604]).

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173930 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040693 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mikkaichi T, Suzuki T, Onogawa T, et al. (mart 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. Bibcode:2004PNAS..101.3569M. doi:10.1073/pnas.0304987101. PMC 373503. PMID 14993604.
^ "Entrez Gene: Solute carrier organic anion transporter family member 4C1". Pristupljeno 11. 3. 2016.
^ "UniProt, Q6ZQN7" (jezik: engleski). Pristupljeno 20. 10. 2021.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173930 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040693 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14993604-5] Mikkaichi T, Suzuki T, Onogawa T, et al. (mart 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. Bibcode:2004PNAS..101.3569M. doi:10.1073/pnas.0304987101. PMC 373503. PMID 14993604.

[entrez-6] "Entrez Gene: Solute carrier organic anion transporter family member 4C1". Pristupljeno 11. 3. 2016.

[UniProt-7] "UniProt, Q6ZQN7" (jezik: engleski). Pristupljeno 20. 10. 2021.

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