SOX21

SOX21
Identifikatori
Aliasi	SOX21
Vanjski ID-jevi	OMIM: 604974 MGI: 2654070 HomoloGene: 5143 GeneCards: SOX21
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	94,712,545 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	118,474,442 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • ćelijska komponenta;
Biološki proces	• hair follicle development; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • hair cycle; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • stem cell differentiation; • skin development; • transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:1901227 negative regulation of transcription by RNA polymerase II; • Ćelijska diferencijacija; • central nervous system development; • neuron differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	11166
	223227
	ENSG00000125285
	ENSMUSG00000061517
	Q9Y651
	Q811W0
	NM_007084
	NM_177753
	NP_009015
	NP_808421
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transkripcijski faktor SOX-21 je protein koji je kod ljudi kodiran genom SOX21 ^[5]^[6] Član je porodice transkripcijskih faktora Sox .

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 276 aminokiselina, a molekulska težina 28.580 Da.^[7]

10	20	30	40	50
MSKPVDHVKR	PMNAFMVWSR	AQRRKMAQEN	PKMHNSEISK	RLGAEWKLLT
ESEKRPFIDE	AKRLRAMHMK	EHPDYKYRPR	RKPKTLLKKD	KFAFPVPYGL
GGVADAEHPA	LKAGAGLHAG	AGGGLVPESL	LANPEKAAAA	AAAAAARVFF
PQSAAAAAAA	AAAAAAGSPY	SLLDLGSKMA	EISSSSSGLP	YASSLGYPTA
GAGAFHGAAA	AAAAAAAAAG	GHTHSHPSPG	NPGYMIPCNC	SAWPSPGLQP
PLAYILLPGM	GKPQLDPYPA	AYAAAL

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija[uredi | uredi izvor]

U embrionu kokoši, Sox21 promovira neuronsku ćelijskudiferencijaciju, suzbijajući aktivnost Sox1, Sox2 i Sox3, koji održavaju neuronske ćelije u nediferenciranom stanju.^[8]

SOX21 nokaut-miševs eksprimira gubitak dlake, počevši od 11. dana nakon porođaja. Ponovni rast započeo je nekoliko dana kasnije, ali je uslijedio ponovni gubitak dlake. Sox21 je također eksprimiran i u kutikulaama dlake kod ljudi, pa bi varijante gena Sox21 mogle biti odgovorne za neka stanja opadanja kose.^[9]

Također pogledajte[uredi | uredi izvor]

SOX geni

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125285 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061517 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. S2CID 27862567.
^ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21".
^ "UniProt, Q9Y651". Pristupljeno 11. 9. 2017.
^ Sandberg M, Källström M, Muhr J (Aug 2005). "Sox21 promotes the progression of vertebrate neurogenesis". Nature Neuroscience. 8 (8): 995–1001. doi:10.1038/nn1493. PMID 15995704. S2CID 25515445.
^ Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y (Jun 2009). "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proceedings of the National Academy of Sciences of the United States of America. 106 (23): 9292–7. Bibcode:2009PNAS..106.9292K. doi:10.1073/pnas.0808324106. PMC 2695080. PMID 19470461. Sažetak – Reuters UK.

Dopunska literatura[uredi | uredi izvor]

Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Cremazy F, Soullier S, Berta P, Jay P (Nov 1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Letters. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568. S2CID 551497.
Stevanović M, Lovell-Badge R, Collignon J, Goodfellow PN (Dec 1993). "SOX3 is an X-linked gene related to SRY". Human Molecular Genetics. 2 (12): 2013–8. doi:10.1093/hmg/2.12.2013. PMID 8111369.
Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (Jun 1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125285 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061517 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10441749-5] Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. S2CID 27862567.

[entrez-6] "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21".

[UniProt-7] "UniProt, Q9Y651". Pristupljeno 11. 9. 2017.

[pmid15995704-8] Sandberg M, Källström M, Muhr J (Aug 2005). "Sox21 promotes the progression of vertebrate neurogenesis". Nature Neuroscience. 8 (8): 995–1001. doi:10.1038/nn1493. PMID 15995704. S2CID 25515445.

[pmid19470461-9] Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y (Jun 2009). "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proceedings of the National Academy of Sciences of the United States of America. 106 (23): 9292–7. Bibcode:2009PNAS..106.9292K. doi:10.1073/pnas.0808324106. PMC 2695080. PMID 19470461. Sažetak – Reuters UK.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]