SRCAP

SRCAP
Identifikatori
Aliasi	SRCAP
Vanjski ID-jevi	OMIM: 611421 MGI: 2444036 HomoloGene: 38213 GeneCards: SRCAP
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	30,741,409 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	127,160,391 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001105 transcription coactivator activity; • nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • hydrolase activity; • GO:0008026 helicase activity; • histone acetyltransferase activity; • ATPase activity; • GO:0031493 histone binding;
Ćelijska komponenta	• perinuklearno područje citoplazme; • Golđijev aparat; • jedro; • nukleoplazma; • nuclear body; • GO:0009327 makromolekulani kompleks; • Swr1 complex;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0022415 viral process; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • histone acetylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • positive regulation of nucleic acid-templated transcription; • chromatin remodeling; • GO:0035042 histone exchange;
	Izvori:Amigo / QuickGO
Ortolozi
	10847
	100043597
	ENSG00000080603
	ENSMUSG00000053877
	Q6ZRS2
	n/a
	NM_006662
	NM_001033881; NM_001304266; NM_175144; NM_178800
	NP_006653
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Helikaza SRCAP je enzim koji je kod ljudi kodiran genom SRCAP.^[5]^[6]^[7]

Pomoći radiajacijske hibridne analize, Nagase et al. (1997) mapirali su gen SRCAP na hromosomu 16.^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 3.230 aminokiselina, a molekulska težina 343.555 Da.^[9].

10	20	30	40	50
MQSSPSPAHP	QLPVLQTQMV	SDGMTGSNPV	SPASSSSPAS	SGAGGISPQH
IAQDSSLDGP	PGPPDGATVP	LEGFSLSQAA	DLANKGPKWE	KSHAEIAEQA
KHEAEIETRI	AELRKEGFWS	LKRLPKVPEP	PRPKGHWDYL	CEEMQWLSAD
FAQERRWKRG	VARKVVRMVI	RHHEEQRQKE	ERARREEQAK	LRRIASTMAK
DVRQFWSNVE	KVVQFKQQSR	LEEKRKKALD	LHLDFIVGQT	EKYSDLLSQS
LNQPLTSSKA	GSSPCLGSSS	AASSPPPPAS	RLDDEDGDFQ	PQEDEEEDDE
ETIEVEEQQE	GNDAEAQRRE	IELLRREGEL	PLEELLRSLP	PQLLEGPSSP
SQTPSSHDSD	TRDGPEEGAE	EEPPQVLEIK	PPPSAVTQRN	KQPWHPDEDD
EEFTANEEEA	EDEEDTIAAE	EQLEGEVDHA	MELSELAREG	ELSMEELLQQ
YAGAYAPGSG	SSEDEDEDEV	DANSSDCEPE	GPVEAEEPPQ	EDSSSQSDSV
EDRSEDEEDE	HSEEEETSGS	SASEESESEE	SEDAQSQSQA	DEEEEDDDFG
VEYLLARDEE	QSEADAGSGP	PTPGPTTLGP	KKEITDIAAA	AESLQPKGYT
LATTQVKTPI	PLLLRGQLRE	YQHIGLDWLV	TMYEKKLNGI	LADEMGLGKT
IQTISLLAHL	ACEKGNWGPH	LIIVPTSVML	NWEMELKRWC	PSFKILTYYG
AQKERKLKRQ	GWTKPNAFHV	CITSYKLVLQ	DHQAFRRKNW	RYLILDEAQN
IKNFKSQRWQ	SLLNFNSQRR	LLLTGTPLQN	SLMELWSLMH	FLMPHVFQSH
REFKEWFSNP	LTGMIEGSQE	YNEGLVKRLH	KVLRPFLLRR	VKVDVEKQMP
KKYEHVIRCR	LSKRQRCLYD	DFMAQTTTKE	TLATGHFMSV	INILMQLRKV
CNHPNLFDPR	PVTSPFITPG	ICFSTASLVL	RATDVHPLQR	IDMGRFDLIG
LEGRVSRYEA	DTFLPRHRLS	RRVLLEVATA	PDPPPRPKPV	KMKVNRMLQP
VPKQEGRTVV	VVNNPRAPLG	PVPVRPPPGP	ELSAQPTPGP	VPQVLPASLM
VSASPAGPPL	IPASRPPGPV	LLPPLQPNSG	SLPQVLPSPL	GVLSGTSRPP
TPTLSLKPTP	PAPVRLSPAP	PPGSSSLLKP	LTVPPGYTFP	PAAATTTSTT
TATATTTAVP	APTPAPQRLI	LSPDMQARLP	SGEVVSIGQL	ASLAQRPVAN
AGGSKPLTFQ	IQGNKLTLTG	AQVRQLAVGQ	PRPLQRNVVH	LVSAGGQHHL
ISQPAHVALI	QAVAPTPGPT	PVSVLPSSTP	STTPAPTGLS	LPLAANQVPP
TMVNNTGVVK	IVVRQAPRDG	LTPVPPLAPA	PRPPSSGLPA	VLNPRPTLTP
GRLPTPTLGT	ARAPMPTPTL	VRPLLKLVHS	PSPEVSASAP	GAAPLTISSP
LHVPSSLPGP	ASSPMPIPNS	SPLASPVSST	VSVPLSSSLP	ISVPTTLPAP
ASAPLTIPIS	APLTVSASGP	ALLTSVTPPL	APVVPAAPGP	PSLAPSGASP
SASALTLGLA	TAPSLSSSQT	PGHPLLLAPT	SSHVPGLNST	VAPACSPVLV
PASALASPFP	SAPNPAPAQA	SLLAPASSAS	QALATPLAPM	AAPQTAILAP
SPAPPLAPLP	VLAPSPGAAP	VLASSQTPVP	VMAPSSTPGT	SLASASPVPA
PTPVLAPSST	QTMLPAPVPS	PLPSPASTQT	LALAPALAPT	LGGSSPSQTL
SLGTGNPQGP	FPTQTLSLTP	ASSLVPTPAQ	TLSLAPGPPL	GPTQTLSLAP
APPLAPASPV	GPAPAHTLTL	APASSSASLL	APASVQTLTL	SPAPVPTLGP
AAAQTLALAP	ASTQSPASQA	SSLVVSASGA	APLPVTMVSR	LPVSKDEPDT
LTLRSGPPSP	PSTATSFGGP	RPRRQPPPPP	RSPFYLDSLE	EKRKRQRSER
LERIFQLSEA	HGALAPVYGT	EVLDFCTLPQ	PVASPIGPRS	PGPSHPTFWT
YTEAAHRAVL	FPQQRLDQLS	EIIERFIFVM	PPVEAPPPSL	HACHPPPWLA
PRQAAFQEQL	ASELWPRARP	LHRIVCNMRT	QFPDLRLIQY	DCGKLQTLAV
LLRQLKAEGH	RVLIFTQMTR	MLDVLEQFLT	YHGHLYLRLD	GSTRVEQRQA
LMERFNADKR	IFCFILSTRS	GGVGVNLTGA	DTVVFYDSDW	NPTMDAQAQD
RCHRIGQTRD	VHIYRLISER	TVEENILKKA	NQKRMLGDMA	IEGGNFTTAY
FKQQTIRELF	DMPLEEPSSS	SVPSAPEEEE	ETVASKQTHI	LEQALCRAED
EEDIRAATQA	KAEQVAELAE	FNENDGFPAG	EGEEAGRPGA	EDEEMSRAEQ
EIAALVEQLT	PIERYAMKFL	EASLEEVSRE	ELKQAEEQVE	AARKDLDQAK
EEVFRLPQEE	EEGPGAGDES	SCGTGGGTHR	RSKKAKAPER	PGTRVSERLR
GARAETQGAN	HTPVISAHQT	RSTTTPPRCS	PARERVPRPA	PRPRPTPASA
PAAIPALVPV	PVSAPVPISA	PNPITILPVH	ILPSPPPPSQ	IPPCSSPACT
PPPACTPPPA	HTPPPAQTCL	VTPSSPLLLG	PPSVPISASV	TNLPLGLRPE
AELCAQALAS	PESLELASVA	SSETSSLSLV	PPKDLLPVAV	EILPVSEKNL
SLTPSAPSLT	LEAGSIPNGQ	EQEAPDSAEG	TTLTVLPEGE	ELPLCVSESN
GLELPPSAAS	DEPLQEPLEA	DRTSEELTEA	KTPTSSPEKP	QELVTAEVAA
PSTSSSATSS	PEGPSPARPP	RRRTSADVEI	RGQGTGRPGQ	PPGPKVLRKL
PGRLVTVVEE	KELVRRRRQQ	RGAASTLVPG	VSETSASPGS	PSVRSMSGPE
SSPPIGGPCE	AAPSSSLPTP	PQQPFIARRH	IELGVTGGGS	PENGDGALLA
ITPPAVKRRR	GRPPKKNRSP	ADAGRGVDEA	PSSTLKGKTN	GADPVPGPET
LIVADPVLEP	QLIPGPQPLG	PQPVHRPNPL	LSPVEKRRRG	RPPKARDLPI
PGTISSAGDG	NSESRTQPPP	HPSPLTPLPP	LLVCPTATVA	NTVTTVTIST
SPPKRKRGRP	PKNPPSPRPS	QLPVLDRDST	SVLESCGLGR	RRQPQGQGES
EGSSSDEDGS	RPLTRLARLR	LEAEGMRGRK	SGGSMVVAVI	QDDLDLADSG
PGGLELTPPV	VSLTPKLRST	RLRPGSLVPP	LETEKLPRKR	AGAPVGGSPG
LAKRGRLQPP	SPLGPEGSVE	ESEAEASGEE	EEGDGTPRRR	PGPRRLVGTT
NQGDQRILRS	SAPPSLAGPA	VSHRGRKAKT

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080603 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053877 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.
^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
^ "Entrez Gene: SRCAP Snf2-related CBP activator protein".
^ Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997. PubMed: 9205841
^ "UniProt, Q6ZRS2". Pristupljeno 9. 7. 2021.

Dopunska literatura[uredi | uredi izvor]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ghosh AK, Majumder M, Steele R, et al. (2000). "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP". J. Biol. Chem. 275 (10): 7184–8. doi:10.1074/jbc.275.10.7184. PMID 10702287.
Xu X, Chackalaparampil I, Monroy MA, et al. (2001). "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription". J. Virol. 75 (21): 10033–40. doi:10.1128/JVI.75.21.10033-10040.2001. PMC 114578. PMID 11581372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Monroy MA, Schott NM, Cox L, et al. (2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1". Mol. Endocrinol. 17 (12): 2519–28. doi:10.1210/me.2003-0208. PMID 14500758.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Eissenberg JC, Wong M, Chrivia JC (2005). "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway". Mol. Cell. Biol. 25 (15): 6559–69. doi:10.1128/MCB.25.15.6559-6569.2005. PMC 1190335. PMID 16024792.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ruhl DD, Jin J, Cai Y, et al. (2006). "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes". Biochemistry. 45 (17): 5671–7. doi:10.1021/bi060043d. PMID 16634648.
Cai Y, Jin J, Gottschalk AJ, et al. (2007). "Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes". Methods. 40 (4): 312–7. doi:10.1016/j.ymeth.2006.06.023. PMC 3092633. PMID 17101442.
Wong MM, Cox LK, Chrivia JC (2007). "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters". J. Biol. Chem. 282 (36): 26132–9. doi:10.1074/jbc.M703418200. PMID 17617668.

Vanjski linkovi[uredi | uredi izvor]

OMIM entry on Floating-Harbor syndrome and SRCAP

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080603 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053877 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10347196-5] Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.

[pmid9205841-6] Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.

[entrez-7] "Entrez Gene: SRCAP Snf2-related CBP activator protein".

[8] Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997. PubMed: 9205841

[UniProt-9] "UniProt, Q6ZRS2". Pristupljeno 9. 7. 2021.

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