STATH

STATH
Identifikatori
Aliasi	STATH
Vanjski ID-jevi	OMIM: 184470 HomoloGene: 88673 GeneCards: STATH
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	70,002,570 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• extracellular matrix constituent, lubricant activity; • hydroxyapatite binding; • structural constituent of tooth enamel; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region;
Biološki proces	• defense response to bacterium; • negative regulation of bone mineralization; • ossification; • saliva secretion; • biomineral tissue development; • regulation of bone mineralization;
	Izvori:Amigo / QuickGO
Ortolozi
	6779
	n/a
	ENSG00000282891; ENSG00000126549
	n/a
	P02808
	n/a
	NM_003154; NM_001009181
	n/a
	NP_001009181; NP_003145
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Staterin jest protein koji je kod ljudi kodiran genom STATH sa hromosoma 4.^[3]^[4]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 62 aminokiseline, а molekulska težina 7.304 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10		20		30		40		50
MKFLVFAFIL		ALMVSMIGAD		SSEEKFLRRI		GRFGYGYGPY		QPVPEQPLYP
QPYQPQYQQY		TF

Funkcija[uredi | uredi izvor]

Ovaj protein sprečava taloženje kalcij-fosfata u pljuvački, održavajući visok nivo kalcijuma u dostupnog za remineralizaciju zubne cakline i visoke nivoe fosfata za puferovanje.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000126549 GRCh38: Ensembl release 89: ENSG00000282891, ENSG00000126549 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sabatini LM, Carlock LR, Johnson GW, Azen EA (Jan 1988). "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva". Am J Hum Genet. 41 (6): 1048–60. PMC 1684366. PMID 3502720.
^ "Entrez Gene: STATH statherin".
^ "UniProt, P02808" (jezik: engleski). Pristupljeno 31. 10. 2021.
^ Hay DI, Smith DJ, Schluckebier SK, Moreno EC (1984). "Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva". J. Dent. Res. 63 (6): 857–63. doi:10.1177/00220345840630060901. PMID 6429216. S2CID 72916849.

Dopunska literatura[uredi | uredi izvor]

Schlesinger DH, Hay DI (1977). "Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva". J. Biol. Chem. 252 (5): 1689–95. PMID 838735.
Raj PA, Johnsson M, Levine MJ, Nancollas GH (1992). "Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization". J. Biol. Chem. 267 (9): 5968–76. PMID 1313424.
Douglas WH, Reeh ES, Ramasubbu N, Raj PA, Bhandary KK, Levine MJ (1991). "Statherin: a major boundary lubricant of human saliva". Biochem. Biophys. Res. Commun. 180 (1): 91–7. doi:10.1016/S0006-291X(05)81259-8. PMID 1718282.
Johnsson M, Richardson CF, Bergey EJ, Levine MJ, Nancollas GH (1992). "The effects of human salivary cystatins and statherin on hydroxyapatite crystallization". Arch. Oral Biol. 36 (9): 631–6. doi:10.1016/0003-9969(91)90014-L. PMID 1741693.
Ramasubbu N, Reddy MS, Bergey EJ, Haraszthy GG, Soni SD, Levine MJ (1992). "Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva". Biochem. J. 280 ( Pt 2) (Pt 2): 341–52. doi:10.1042/bj2800341. PMC 1130552. PMID 1747107.
Sabatini LM, He YZ, Azen EA (1990). "Structure and sequence determination of the gene encoding human salivary statherin". Gene. 89 (2): 245–51. doi:10.1016/0378-1119(90)90012-G. PMID 2373369.
Sabatini LM, Warner TF, Saitoh E, Azen EA (1990). "Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques". J. Dent. Res. 68 (7): 1138–45. doi:10.1177/00220345890680070101. PMID 2483725. S2CID 36679891.
Dickinson DP, Ridall AL, Levine MJ (1988). "Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence". Biochem. Biophys. Res. Commun. 149 (2): 784–90. doi:10.1016/0006-291X(87)90436-0. PMID 3426601.
Oppenheim FG, Hay DI, Smith DJ, Offner GD, Troxler RF (1987). "Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides". J. Dent. Res. 66 (2): 462–6. doi:10.1177/00220345870660021301. PMID 3476566. S2CID 22104713.
Perinpanayagam HE, Van Wuyckhuyse BC, Ji ZS, Tabak LA (1995). "Characterization of low-molecular-weight peptides in human parotid saliva". J. Dent. Res. 74 (1): 345–50. doi:10.1177/00220345950740011001. PMID 7876428. S2CID 19598742.
Gururaja TL, Levine MJ (1997). "Solid-phase synthesis and characterization of human salivary statherin: a tyrosine-rich phosphoprotein inhibitor of calcium phosphate precipitation". Pept. Res. 9 (6): 283–9. PMID 9048421.
Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822. S2CID 39525421.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974. S2CID 27558675.
Gilbert M, Shaw WJ, Long JR, Nelson K, Drobny GP, Giachelli CM, Stayton PS (2000). "Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion". J. Biol. Chem. 275 (21): 16213–8. doi:10.1074/jbc.M001773200. PMID 10748043.
Yao Y, Lamkin MS, Oppenheim FG (2000). "Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin generated by transglutaminase". J. Dent. Res. 79 (4): 930–8. doi:10.1177/00220345000790040801. PMID 10831095. S2CID 37029459.
Tamaki N, Tada T, Morita M, Watanabe T (2003). "Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1". Calcif. Tissue Int. 71 (1): 59–62. doi:10.1007/s00223-001-1084-0. PMID 12060866. S2CID 38221230.
Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG (2003). "Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches". J. Biol. Chem. 278 (7): 5300–8. doi:10.1074/jbc.M206333200. PMID 12444093.

[refGRCh38Ensembl-1] ENSG00000126549 GRCh38: Ensembl release 89: ENSG00000282891, ENSG00000126549 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3502720-3] Sabatini LM, Carlock LR, Johnson GW, Azen EA (Jan 1988). "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva". Am J Hum Genet. 41 (6): 1048–60. PMC 1684366. PMID 3502720.

[entrez-4] "Entrez Gene: STATH statherin".

[UniProt-5] "UniProt, P02808" (jezik: engleski). Pristupljeno 31. 10. 2021.

[pmid6429216-6] Hay DI, Smith DJ, Schluckebier SK, Moreno EC (1984). "Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva". J. Dent. Res. 63 (6): 857–63. doi:10.1177/00220345840630060901. PMID 6429216. S2CID 72916849.

[1]

[2]

[3]

[4]

[5]

[6]