STOX1

STOX1
Identifikatori
Aliasi	STOX1
Vanjski ID-jevi	OMIM: 609397 MGI: 2684909 HomoloGene: 17649 GeneCards: STOX1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	68,895,432 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	62,561,907 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • centrosom; • nukleoplazma; • centar organizacije mikrotubula; • cell cortex; • citoskelet; • jedro; • fibrillar center; • Jedarce; • citosol;
Biološki proces	• positive regulation of protein kinase B signaling; • GO:0009373 regulation of transcription, DNA-templated; • regulation of mitochondrion organization; • regulation of mitochondrial DNA metabolic process; • positive regulation of epithelial cell proliferation; • negative regulation of gene expression; • transcription, DNA-templated; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of cyclin-dependent protein kinase activity; • Ćelijska dioba; • regulation of mitochondrial membrane potential; • GO:1901313 positive regulation of gene expression; • positive regulation of cell cycle; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of cell population proliferation; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • regulation of response to oxidative stress; • Regulacija ekspresije gena; • inner ear development; • positive regulation of G2/M transition of mitotic cell cycle; • ćelijski ciklus; • cellular response to nitrosative stress; • positive regulation of otic vesicle morphogenesis; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	219736
	216021
	ENSG00000165730
	ENSMUSG00000036923
	Q6ZVD7
	B2RQL2
	NM_001130159; NM_001130160; NM_001130161; NM_001130162; NM_152709
	NM_001033260; NM_001364705
	NP_001123631; NP_001123632; NP_001123633; NP_689922
	NP_001028432; NP_001351634
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Rodasta kutija 1 je protein koji je kod ljudi kodiran genom STOX1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 989 aminokiselina, а molekulska težina 110.962 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MARPVQLAPG	SLALVLCRLE	AQKAAGAAEE	PGGRAVFRAF	RRANARCFWN
ARLARAASRL	AFQGWLRRGV	LLVRAPPACL	QVLRDAWRRR	ALRPPRGFRI
RAVGDVFPVQ	MNPITQSQFV	PLGEVLCCAI	SDMNTAQIVV	TQESLLERLM
KHYPGIAIPS	EDILYTTLGT	LIKERKIYHT	GEGYFIVTPQ	TYFITNTTTQ
ENKRMLPSDE	SRLMPASMTY	LVSMESCAES	AQENAAPISH	CQSCQCFRDM
HTQDVQEAPV	AAEVTRKSHR	GLGESVSWVQ	NGAVSVSAEH	HICESTKPLP
YTRDKEKGKK	FGFSLLWRSL	SRKEKPKTEH	SSFSAQFPPE	EWPVRDEDDL
DNIPRDVEHE	IIKRINPILT	VDNLIKHTVL	MQKYEEQKKY	NSQGTSTDML
TIGHKYPSKE	GVKKRQGLSA	KPQGQGHSRR	DRHKARNQGS	EFQPGSIRLE
KHPKLPATQP	IPRIKSPNEM	VGQKPLGEIT	TVLGSHLIYK	KRISNPFQGL
SHRGSTISKG	HKIQKTSDLK	PSQTGPKEKP	FQKPRSLDSS	RIFDGKAKEP
YAEQPNDKME	AESIYINDPT	VKPINDDFRG	HLFSHPQQSM	LQNDGKCCPF
MESMLRYEVY	GGENEVIPEV	LRKSHSHFDK	LGETKQTPHS	LPSRGASFSD
RTPSACRLVD	NTIHQFQNLG	LLDYPVGVNP	LRQAARQDKD	SEELLRKGFV
QDAETTSLEN	EQLSNDDQAL	YQNEVEDDDG	ACSSLYLEED	DISENDDLRQ
MLPGHSQYSF	TGGSQGNHLG	KQKVIERSLT	EYNSTMERVE	SQVLKRNECY
KPTGLHATPG	ESQEPNLSAE	SCGLNSGAQF	GFNYEEEPSV	AKCVQASAPA
DERIFDYYSA	RKASFEAEVI	QDTIGDTGKK	PASWSQSPQN	QEMRKHFPQK
FQLFNTSHMP	VLAQDVQYEH	SHLEGTENHS	MAGDSGIDSP	RTQSLGSNNS
VILDGLKRRQ	NFLQNVEGTK	SSQPLTSNSL	LPLTPVINV

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom može funkcionirati kao protein koji veže DNK. Mutacije u ovom genu povezane su s preeklampsijom/eklampsijom 4 (PEE4). Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme (prema RefSeq, Sep 2009).

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165730 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036923 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Storkhead box 1". Pristupljeno 24. 3. 2013.
^ "UniProt, Q6ZVD7". Pristupljeno 5. 9. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165730 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036923 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Storkhead box 1". Pristupljeno 24. 3. 2013.

[UniProt-6] "UniProt, Q6ZVD7". Pristupljeno 5. 9. 2021.

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