STT3B
Podjedinica STT3B dolihil-difosfooligosaharid-protein glikoziltransferaze jest enzim koji je kod ljudi kodiran genom STT3B sa hromosoma 3.[5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 826 aminokiselina, а molekulska težina 93.674 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAEPSAPESK | HKSSLNSSPW | SGLMALGNSR | HGHHGPGAQC | AHKAAGGAAP | ||||
| PKPAPAGLSG | GLSQPAGWQS | LLSFTILFLA | WLAGFSSRLF | AVIRFESIIH | ||||
| EFDPWFNYRS | THHLASHGFY | EFLNWFDERA | WYPLGRIVGG | TVYPGLMITA | ||||
| GLIHWILNTL | NITVHIRDVC | VFLAPTFSGL | TSISTFLLTR | ELWNQGAGLL | ||||
| AACFIAIVPG | YISRSVAGSF | DNEGIAIFAL | QFTYYLWVKS | VKTGSVFWTM | ||||
| CCCLSYFYMV | SAWGGYVFII | NLIPLHVFVL | LLMQRYSKRV | YIAYSTFYIV | ||||
| GLILSMQIPF | VGFQPIRTSE | HMAAAGVFAL | LQAYAFLQYL | RDRLTKQEFQ | ||||
| TLFFLGVSLA | AGAVFLSVIY | LTYTGYIAPW | SGRFYSLWDT | GYAKIHIPII | ||||
| ASVSEHQPTT | WVSFFFDLHI | LVCTFPAGLW | FCIKNINDER | VFVALYAISA | ||||
| VYFAGVMVRL | MLTLTPVVCM | LSAIAFSNVF | EHYLGDDMKR | ENPPVEDSSD | ||||
| EDDKRNQGNL | YDKAGKVRKH | ATEQEKTEEG | LGPNIKSIVT | MLMLMLLMMF | ||||
| AVHCTWVTSN | AYSSPSVVLA | SYNHDGTRNI | LDDFREAYFW | LRQNTDEHAR | ||||
| VMSWWDYGYQ | IAGMANRTTL | VDNNTWNNSH | IALVGKAMSS | NETAAYKIMR | ||||
| TLDVDYVLVI | FGGVIGYSGD | DINKFLWMVR | IAEGEHPKDI | RESDYFTPQG | ||||
| EFRVDKAGSP | TLLNCLMYKM | SYYRFGEMQL | DFRTPPGFDR | TRNAEIGNKD | ||||
| IKFKHLEEAF | TSEHWLVRIY | KVKAPDNRET | LDHKPRVTNI | FPKQKYLSKK | ||||
| TTKRKRGYIK | NKLVFKKGKK | ISKKTV |
Funkcija[uredi | uredi izvor]
STT3B protein sadrži visoko imunogeni epitop manjeg histokompatibilnog antigena od devet aminokiselina, B6(dom1). Poput ITM1 (MIM 601134), STT3B je homologan sa STT3 kvasca, oligosahariltransferaza neophodna za proliferaciju ćelija.[7][9]
Također pogledajte[uredi | uredi izvor]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (juli 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
- ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
- ^ a b "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
- ^ "UniProt, Q8TCJ2" (jezik: engleski). Pristupljeno 5. 11. 2021.
- ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. Springer Science and Business Media LLC. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
Dopunska literatura[uredi | uredi izvor]
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (april 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.