STX1B

STX1B
Identifikatori
Aliasi	STX1B
Vanjski ID-jevi	OMIM: 601485 MGI: 1930705 HomoloGene: 69375 GeneCards: STX1B
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	31,010,638 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	127,423,721 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• SNAP receptor activity; • protein kinase binding; • signaling receptor binding; • SNARE binding; • protein domain specific binding;
Ćelijska komponenta	• integral component of membrane; • citosol; • membrana; • Sinapsna vezikula; • ćelijska membrana; • Diobeno vreteno; • centar organizacije mikrotubula; • SNARE complex; • citoskelet; • Jedarna lamina; • jedro; • nukleoplazma; • centrosom; • citoplazma; • presynaptic membrane; • presynapse; • presynaptic active zone membrane; • Akson; • Nervno-mišićna veza; • Endomembranski sistem;
Biološki proces	• synaptic vesicle docking; • spontaneous neurotransmitter secretion; • positive regulation of neurotransmitter secretion; • regulation of exocytosis; • vesicle docking; • positive regulation of excitatory postsynaptic potential; • Regulacija ekspresije gena; • protein transport; • intracellular protein transport; • neurotransmitter transport; • vesicle-mediated transport; • regulation of synaptic vesicle priming; • negative regulation of neuron projection development; • regulation of synaptic activity; • vesicle docking involved in exocytosis; • calcium ion-regulated exocytosis of neurotransmitter; • protein localization to membrane; • negative regulation of synaptic vesicle recycling; • positive regulation of spontaneous neurotransmitter secretion; • negative regulation of macropinocytosis; • synaptic vesicle fusion to presynaptic active zone membrane; • exocytic insertion of neurotransmitter receptor to postsynaptic membrane; • synaptic vesicle exocytosis; • Egzocitoza; • Fuzija vezikula;
	Izvori:Amigo / QuickGO
Ortolozi
	112755
	56216
	ENSG00000099365
	ENSMUSG00000030806
	P61266
	P61264
	NM_052874
	NM_024414
	NP_443106
	NP_077725
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintaksin-1B jest protein koji je kod ljudi kodiran genom STX1B sa hromosoma 16.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 288 aminokiselina, a molekulska težina 33.245 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKDRTQELRS	AKDSDDEEEV	VHVDRDHFMD	EFFEQVEEIR	GCIEKLSEDV
EQVKKQHSAI	LAAPNPDEKT	KQELEDLTAD	IKKTANKVRS	KLKAIEQSIE
QEEGLNRSSA	DLRIRKTQHS	TLSRKFVEVM	TEYNATQSKY	RDRCKDRIQR
QLEITGRTTT	NEELEDMLES	GKLAIFTDDI	KMDSQMTKQA	LNEIETRHNE
IIKLETSIRE	LHDMFVDMAM	LVESQGEMID	RIEYNVEHSV	DYVERAVSDT
KKAVKYQSKA	RRKKIMIIIC	CVVLGVVLAS	SIGGTLGL

Interakcije[uredi | uredi izvor]

Pokazano je da STX1B ima interakcije sa UNC13B.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099365 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030806 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: STX1B2 syntaxin 1B2".
^ Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

Dopunska literatura[uredi | uredi izvor]

Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. PMID 11112705.
Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (September 1996). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization". Genomics. 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
Smirnova T, Stinnakre J, Mallet J (October 1993). "Characterization of a presynaptic glutamate receptor". Science. 262 (5132): 430–3. doi:10.1126/science.8105537. PMID 8105537.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099365 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030806 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STX1B2 syntaxin 1B2".

[pmid8999968-6] Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

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