S Wikipedije, slobodne enciklopedije
Hemokinoliki protein TAFA-5protein koji je kod ljudi kodiran genom TAFA5 sa hromosoma 22 .[5] [6]
Dužina polipeptidnog lanca je 132 aminokiseline , a molekulska težina 14.301 Da .[6]
10 20 30 40 50 MAPSPRTGSR QDATALPSMS STFWAFMILA SLLIAYCSQL AAGTCEIVTL DRDSSQPRRT IARQTARCAC RKGQIAGTTR ARPACVDARI IKTKQWCDML PCLEGEGCDL LINRSGWTCT QPGGRIKTTT VS
Ovaj gen je član porodice TAFA koja se sastoji od pet visoko homolognih gena koji kodiraju male sekretne proteine . Ovi proteini sadrže konzervirane cisteinske ostatke na fiksnim pozicijama i udaljeni su sa CCL3 , članom porodice CC-hemokina . TAFA proteini su pretežno eksprimirani u specifičnim regijama mozga i pretpostavlja se da funkcionišu kao hemokini ili neurokini , specifični za mozak, koji djeluju kao regulatori imunskih i nervnih ćelija .[6]
^ a b c GRCh38: Ensembl release 89: ENSG00000219438 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054863 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics . 83 (4): 727–34. doi :10.1016/j.ygeno.2003.10.006 . PMID 15028294 . ^ a b c "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]" . National Center for Biotechnology Information . Pristupljeno 11 August 2019 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . 
