TELO2
TEL2 homolog regulacijskog proteina telomerne dužine je protein koji je kod ljudi kodiran genom TELO2.[5][6][7][8]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 837 aminokiselina, a molekulska težina 91.747 Da.[9].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEPAPSEVRL | AVREAIHALS | SSEDGGHIFC | TLESLKRYLG | EMEPPALPRE | ||||
| KEEFASAHFS | PVLRCLASRL | SPAWLELLPH | GRLEELWASF | FLEGPADQAF | ||||
| LVLMETIEGA | AGPSFRLMKM | ARLLARFLRE | GRLAVLMEAQ | CRQQTQPGFI | ||||
| LLRETLLGKV | VALPDHLGNR | LQQENLAEFF | PQNYFRLLGE | EVVRVLQAVV | ||||
| DSLQGGLDSS | VSFVSQVLGK | ACVHGRQQEI | LGVLVPRLAA | LTQGSYLHQR | ||||
| VCWRLVEQVP | DRAMEAVLTG | LVEAALGPEV | LSRLLGNLVV | KNKKAQFVMT | ||||
| QKLLFLQSRL | TTPMLQSLLG | HLAMDSQRRP | LLLQVLKELL | ETWGSSSAIR | ||||
| HTPLPQQRHV | SKAVLICLAQ | LGEPELRDSR | DELLASMMAG | VKCRLDSSLP | ||||
| PVRRLGMIVA | EVVSARIHPE | GPPLKFQYEE | DELSLELLAL | ASPQPAGDGA | ||||
| SEAGTSLVPA | TAEPPAETPA | EIVDGGVPQA | QLAGSDSDLD | SDDEFVPYDM | ||||
| SGDRELKSSK | APAYVRDCVE | ALTTSEDIER | WEAALRALEG | LVYRSPTATR | ||||
| EVSVELAKVL | LHLEEKTCVV | GFAGLRQRAL | VAVTVTDPAP | VADYLTSQFY | ||||
| ALNYSLRQRM | DILDVLTLAA | QELSRPGCLG | RTPQPGSPSP | NTPCLPEAAV | ||||
| SQPGSAVASD | WRVVVEERIR | SKTQRLSKGG | PRQGPAGSPS | RFNSVAGHFF | ||||
| FPLLQRFDRP | LVTFDLLGED | QLVLGRLAHT | LGALMCLAVN | TTVAVAMGKA | ||||
| LLEFVWALRF | HIDAYVRQGL | LSAVSSVLLS | LPAARLLEDL | MDELLEARSW | ||||
| LADVAEKDPD | EDCRTLALRA | LLLLQRLKNR | LLPPASP |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Funkcija[uredi | uredi izvor]
U 2007. istraživači su izvijestili o neočekivanoj ulozi Tel2 u ekspresiji svih proteinskih kinaza povezanih s sisarskim fosfatidilinozitol 3-kinazama (kinaza PIKK). Iako je Tel2 identificiran kao gen pupajućeg kvasca potreban za održavanje dužine telomera, nisu pronašli očiglednu telomernu funkciju sisarskog Tel2. Delecija Tel2 zaustavila je mTOR signalizaciju, ukazujući da Tel2 utiče na PIKK sisara. Tel2 se veže na dio HEAT-ponavljanja segmenata ATM-a i mTOR-a i visoko je konzervirani regulator stabilnosti PIKK-a.[10]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
- ^ "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
- ^ "UniProt, Q9Y4R8". Pristupljeno 9. 7. 2021.
- ^ Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.
Dopunska literatura[uredi | uredi izvor]
- Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.