THAP4

THAP4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3IA8
Identifikatori
Aliasi	THAP4
Vanjski ID-jevi	OMIM: 612533 MGI: 1914276 HomoloGene: 12075 GeneCards: THAP4
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	241,637,158 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	93,682,586 bp
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • vezivanje sa DNK; • nucleic acid binding; • heme binding; • protein homodimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• ćelijska komponenta;
Biološki proces	• GO:0022610 biološki proces; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	51078
	67026
	ENSG00000176946
	ENSMUSG00000026279
	Q8WY91
	Q6P3Z3
	NM_001164356; NM_015963
	NM_025920; NM_001310761
	NP_001157828; NP_057047
	NP_001297690; NP_080196
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 4 sa THAP domenom jest protein koji je kod ljudi kodiran genom THAP4 sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 577 aminokiselina, a molekulska težina 62.890 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVICCAAVNC	SNRQGKGEKR	AVSFHRFPLK	DSKRLIQWLK	AVQRDNWTPT
KYSFLCSEHF	TKDSFSKRLE	DQHRLLKPTA	VPSIFHLTEK	KRGAGGHGRT
RRKDASKATG	GVRGHSSAAT	SRGAAGWSPS	SSGNPMAKPE	SRRLKQAALQ
GEATPRAAQE	AASQEQAQQA	LERTPGDGLA	TMVAGSQGKA	EASATDAGDE
SATSSIEGGV	TDKSGISMDD	FTPPGSGACK	FIGSLHSYSF	SSKHTRERPS
VPREPIDRKR	LKKDVEPSCS	GSSLGPDKGL	AQSPPSSSLT	ATPQKPSQSP
SAPPADVTPK	PATEAVQSEH	SDASPMSINE	VILSASGACK	LIDSLHSYCF
SSRQNKSQVC	CLREQVEKKN	GELKSLRQRV	SRSDSQVRKL	QEKLDELRRV
SVPYPSSLLS	PSREPPKMNP	VVEPLSWMLG	TWLSDPPGAG	TYPTLQPFQY
LEEVHISHVG	QPMLNFSFNS	FHPDTRKPMH	RECGFIRLKP	DTNKVAFVSA
QNTGVVEVEE	GEVNGQELCI	ASHSIARISF	AKEPHVEQIT	RKFRLNSEGK
LEQTVSMATT	TQPMTQHLHV	TYKKVTP

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176946 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026279 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
^ "Entrez Gene: THAP4 THAP domain containing 4".
^ "UniProt, Q8WY91" (jezik: engleski). Pristupljeno 20. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176946 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026279 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12575992-5] Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.

[pmid10810093-6] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[entrez-7] "Entrez Gene: THAP4 THAP domain containing 4".

[UniProt-8] "UniProt, Q8WY91" (jezik: engleski). Pristupljeno 20. 11. 2021.

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