TMBIM1

TMBIM1
Identifikatori
Aliasi	TMBIM1
Vanjski ID-jevi	OMIM: 610364 MGI: 1916910 HomoloGene: 36404 GeneCards: TMBIM1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	218,292,586 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	74,344,781 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• death receptor binding;
Ćelijska komponenta	• integral component of membrane; • lysosomal membrane; • endozom; • Golđijev aparat; • Lizozom; • endosome membrane; • Egzosom; • membrana; • ćelijska membrana; • specific granule membrane; • intracellular membrane-bounded organelle;
Biološki proces	• negative regulation of Fas signaling pathway; • positive regulation of blood vessel remodeling; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • GO:0048553 negative regulation of catalytic activity; • neutrophil degranulation; • negative regulation of protein localization to plasma membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	64114
	69660
	ENSG00000135926
	ENSMUSG00000006301
	Q969X1
	Q8BJZ3
NM_022152; NM_001321427; NM_001321428; NM_001321429; NM_001321430;
	NM_001321432; NM_001321433; NM_001321435; NM_001321436; NM_001321438
	NM_027154
NP_001308356; NP_001308357; NP_001308358; NP_001308359; NP_001308361;
	NP_001308362; NP_001308364; NP_001308365; NP_001308367; NP_071435
	NP_081430
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 sa transmembranskim inhibitornim motivom BAX jest protein koji je kod ljudi kodiran genom TMBIM1 sa hromosoma 2.^[5]^[6]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 311 aminokiselina, a molekulska težina 34.607 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSNPSAPPPY	EDRNPLYPGP	PPPGGYGQPS	VLPGGYPAYP	GYPQPGYGHP
AGYPQPMPPT	HPMPMNYGPG	HGYDGEERAV	SDSFGPGEWD	DRKVRHTFIR
KVYSIISVQL	LITVAIIAIF	TFVEPVSAFV	RRNVAVYYVS	YAVFVVTYLI
LACCQGPRRR	FPWNIILLTL	FTFAMGFMTG	TISSMYQTKA	VIIAMIITAV
VSISVTIFCF	QTKVDFTSCT	GLFCVLGIVL	LVTGIVTSIV	LYFQYVYWLH
MLYAALGAIC	FTLFLAYDTQ	LVLGNRKHTI	SPEDYITGAL	QIYTDIIYIF
TFVLQLMGDR	N

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135926 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006301 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: TMBIM1 transmembrane BAX inhibitor motif containing 1".
^ "UniProt, Q969X1" (jezik: engleski). Pristupljeno 20. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Yoshisue H, Suzuki K, Kawabata A, et al. (2002). "Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library". Atherosclerosis. 162 (2): 323–34. doi:10.1016/S0021-9150(01)00735-3. PMID 11996952.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hwang KC, Cui XS, Park SP, et al. (2005). "Identification of differentially regulated genes in bovine blastocysts using an annealing control primer system". Mol. Reprod. Dev. 69 (1): 43–51. doi:10.1002/mrd.20156. PMID 15278903. S2CID 26276700.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Zhao H, Ito A, Kimura SH, et al. (2007). "RECS1 deficiency in mice induces susceptibility to cystic medial degeneration". Genes Genet. Syst. 81 (1): 41–50. doi:10.1266/ggs.81.41. PMID 16607040.
Zhao H, Ito A, Sakai N, et al. (2006). "RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation". Circ. J. 70 (5): 615–24. doi:10.1253/circj.70.615. PMID 16636500.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135926 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006301 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: TMBIM1 transmembrane BAX inhibitor motif containing 1".

[UniProt-7] "UniProt, Q969X1" (jezik: engleski). Pristupljeno 20. 11. 2021.

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