TMPRSS11D
| TMPRSS11D | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | TMPRSS11D | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 605369 MGI: 2385221 HomoloGene: 74519 GeneCards: TMPRSS11D | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 4: 67.82 – 67.88 Mb | Chr 5: 86.45 – 86.52 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Serin 11D transmembranska proteaza, jest enzim koji je kod ljudi kodiran genom TMPRSS11D sa hromosoma 4.[5][6][7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 46.263 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MYRPARVTST | SRFLNPYVVC | FIVVAGVVIL | AVTIALLVYF | LAFDQKSYFY | ||||
| RSSFQLLNVE | YNSQLNSPAT | QEYRTLSGRI | ESLITKTFKE | SNLRNQFIRA | ||||
| HVAKLRQDGS | GVRADVVMKF | QFTRNNNGAS | MKSRIESVLR | QMLNNSGNLE | ||||
| INPSTEITSL | TDQAAANWLI | NECGAGPDLI | TLSEQRILGG | TEAEEGSWPW | ||||
| QVSLRLNNAH | HCGGSLINNM | WILTAAHCFR | SNSNPRDWIA | TSGISTTFPK | ||||
| LRMRVRNILI | HNNYKSATHE | NDIALVRLEN | SVTFTKDIHS | VCLPAATQNI | ||||
| PPGSTAYVTG | WGAQEYAGHT | VPELRQGQVR | IISNDVCNAP | HSYNGAILSG | ||||
| MLCAGVPQGG | VDACQGDSGG | PLVQEDSRRL | WFIVGIVSWG | DQCGLPDKPG | ||||
| VYTRVTAYLD | WIRQQTGI |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira tripsinu sličnu serin-proteazu koja se oslobađa iz submukozel serozne žlijezde na sluzničnu membranu. To je integralni membranski protein tipa II i ima 29-38% identiteta u sekvenci katalitske regije sa ljudskim hepsinom, enteropeptidazom, akrozinom, i mastocitnom triptazom. Nekatalitska regija ima malo sličnosti s drugim poznatim proteinima. Ovaj protein može imati određenu biološku ulogu u odbrambenom sistemu domaćina na sluzokožama, nezavisno ili u saradnji sa drugim supstancama u sluzokoži disajnih puteva ili bronhijskim sekretima.[7]
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061259 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
- ↑ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
- 1 2 "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D".
- ↑ "UniProt, O60235" (jezik: engleski). Pristupljeno 29. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Takahashi M, Sano T, Yamaoka K, et al. (2001). "Localization of human airway trypsin-like protease in the airway: an immunohistochemical study". Histochem. Cell Biol. 115 (3): 181–7. doi:10.1007/s004180000243. PMID 11326745. S2CID 25025224.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Miki M, Nakamura Y, Takahashi A, et al. (2003). "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells". J. Med. Invest. 50 (1–2): 95–107. PMID 12630574.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Iwakiri K, Ghazizadeh M, Jin E, et al. (2004). "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris". J. Invest. Dermatol. 122 (4): 937–44. doi:10.1111/j.0022-202X.2004.22415.x. PMID 15102084.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Matsushima R, Takahashi A, Nakaya Y, et al. (2006). "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway". Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2): L385–95. doi:10.1152/ajplung.00098.2005. PMID 16199437.
- Chokki M, Eguchi H, Hamamura I, et al. (2006). "Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells". FEBS J. 272 (24): 6387–99. doi:10.1111/j.1742-4658.2005.05035.x. PMID 16336275. S2CID 34294232.
- Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium". J. Virol. 80 (19): 9896–8. doi:10.1128/JVI.01118-06. PMC 1617224. PMID 16973594.