TNFAIP8L2

TNFAIP8L2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3F4M
Identifikatori
Aliasi	TNFAIP8L2
Vanjski ID-jevi	OMIM: 612112 MGI: 1917019 HomoloGene: 56998 GeneCards: TNFAIP8L2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	151,159,749 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	95,049,671 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma;
Biološki proces	• Urođeni imunski sistem; • negative regulation of T cell activation; • negative regulation of inflammatory response; • immune system process; • regulation of apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	79626
	69769
	ENSG00000163154
	ENSMUSG00000013707
	Q6P589
	Q9D8Y7
	NM_024575
	NM_027206
	NP_078851
	NP_081482
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TNF-alfa inducirani protein 8 sličan proteinu 2 (TNFAIP8L2 ili TIPE2) jest protein koji je kod ljudi kodiran genom TNFAIP8L2 sa hromosoma 1. Eksprimiran je prvenstveno u tipovima ljudskih mijeloidnih ćelija i služi kao regulator imunskee kontrolne tačke upala i metabolizma.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 184 aminokiseline, a molekulska težina 20.556 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MESFSSKSLA	LQAEKKLLSK	MAGRSVAHLF	IDETSSEVLD	ELYRVSKEYT
HSRPQAQRVI	KDLIKVAIKV	AVLHRNGSFG	PSELALATRF	RQKLRQGAMT
ALSFGEVDFT	FEAAVLAGLL	TECRDVLLEL	VEHHLTPKSH	GRIRHVFDHF
SDPGLLTALY	GPDFTQHLGK	ICDGLRKLLD	EGKL

Struktura[uredi | uredi izvor]

Kristalna struktura TIPE2 otkriva da sadrži veliku, hidrofobnu centralnu šupljinu koja je spremna za vezivanje kofaktora.^[7]

Funkcija[uredi | uredi izvor]

TNFAIP8L2 je član porodice TNFAIP8 (protein 8 izazvan faktorom nekroze tumora-α ili TIPE) koji funkcionišu kao transferni proteini za drugoglasničke lipide PIP2 i PIP3. Ostala tri člana porodice su TNFAIP8, TNFAIP8L1 i TNFAIP8L3.^[8]

Klinički značaj[uredi | uredi izvor]

TIPE2 djeluje kao negativan regulator imunskog sistema.^[5]^[9] Podreguliran je kod pacijenata sa infektivnim i autoimunskim bolestima, a djeluje i kao tumorski supresor kod nekoliko tipova raka.^[10] Njegov nokaut dovodi do leukocitoze i sistemskih upalnih poremećaja kod miševa.^[8]^[11]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163154 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013707 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Li T, Wang W, et al. (maj 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.
^ "UniProt, Q6P589" (jezik: engleski). Pristupljeno 19. 12. 2021.
^ Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y (januar 2009). "Crystal structure of TIPE2 provides insights into immune homeostasis". Nature Structural & Molecular Biology. 16 (1): 89–90. doi:10.1038/nsmb.1522. PMID 19079267. S2CID 11111978.
^ ^a ^b Goldsmith JR, Chen YH (juni 2017). "Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins". Cellular & Molecular Immunology. 14 (6): 482–487. doi:10.1038/cmi.2017.4. PMC 5719143. PMID 28287114.
^ Sun H, Gong S, et al. (2008). "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis". Cell. 133 (3): 415–26. doi:10.1016/j.cell.2008.03.026. PMC 2398615. PMID 18455983.
^ Li Z, Jia W, Niu J, Zhang L (februar 2018). "Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis". Histology and Histopathology. 33 (9): 919–928. doi:10.14670/HH-11-977. PMID 29480508.
^ Lou Y, Liu S (oktobar 2011). "The TIPE (TNFAIP8) family in inflammation, immunity, and cancer". Molecular Immunology. 49 (1–2): 4–7. doi:10.1016/j.molimm.2011.08.006. PMID 21924498.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163154 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013707 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Li_et_al_2018-5] Li T, Wang W, et al. (maj 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

[UniProt-6] "UniProt, Q6P589" (jezik: engleski). Pristupljeno 19. 12. 2021.

[pmid19079267-7] Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y (januar 2009). "Crystal structure of TIPE2 provides insights into immune homeostasis". Nature Structural & Molecular Biology. 16 (1): 89–90. doi:10.1038/nsmb.1522. PMID 19079267. S2CID 11111978.

[Goldsmith_2017-8] Goldsmith JR, Chen YH (juni 2017). "Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins". Cellular & Molecular Immunology. 14 (6): 482–487. doi:10.1038/cmi.2017.4. PMC 5719143. PMID 28287114.

[pmid18455983-9] Sun H, Gong S, et al. (2008). "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis". Cell. 133 (3): 415–26. doi:10.1016/j.cell.2008.03.026. PMC 2398615. PMID 18455983.

[Li_2018-10] Li Z, Jia W, Niu J, Zhang L (februar 2018). "Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis". Histology and Histopathology. 33 (9): 919–928. doi:10.14670/HH-11-977. PMID 29480508.

[Lou_2011-11] Lou Y, Liu S (oktobar 2011). "The TIPE (TNFAIP8) family in inflammation, immunity, and cancer". Molecular Immunology. 49 (1–2): 4–7. doi:10.1016/j.molimm.2011.08.006. PMID 21924498.

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