TRAK1

TRAK1
Identifikatori
Aliasi	TRAK1
Vanjski ID-jevi	OMIM: 608112 MGI: 1914345 HomoloGene: 25103 GeneCards: TRAK1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	42,225,890 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	121,303,984 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • GABA receptor binding; • TPR domain binding; • signaling receptor binding; • myosin binding;
Ćelijska komponenta	• citoplazma; • endozom; • early endosome; • mitohondrija; • jedro; • axon cytoplasm; • dendrit; • axonal growth cone; • perinuklearno područje citoplazme; • GO:0016023 citoplazmatska vezikula; • dendrite cytoplasm; • cell cortex; • membrana; • mitochondrial membranes;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • Ciljanje proteina; • protein O-linked glycosylation; • endosome to lysosome transport; • anterograde axonal transport of mitochondrion; • axonal transport of mitochondrion; • dendrite morphogenesis; • positive regulation of axonogenesis; • anterograde axonal transport; • GO:0034613 protein localization; • neurogenesis; • vesicle transport along microtubule; • mitochondrion distribution;
	Izvori:Amigo / QuickGO
Ortolozi
	22906
	67095
	ENSG00000182606
	ENSMUSG00000032536
	Q9UPV9
	Q6PD31
NM_001042646; NM_001265608; NM_001265609; NM_001265610; NM_014965;
	NM_001349245; NM_001349246; NM_001349247; NM_001349248; NM_001349249
NM_175114; NM_001357968; NM_001357969; NM_001357970; NM_001357972;
	NM_001357973
NP_001036111; NP_001252537; NP_001252538; NP_001252539; NP_055780;
	NP_001336174; NP_001336175; NP_001336176; NP_001336177; NP_001336178
NP_780323; NP_001344897; NP_001344898; NP_001344899; NP_001344901;
	NP_001344902
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prometujući kinezin-vezujući protein 1 jest protein koji je kod ljudi kodiran genom TRAK1 sa hromosoma 3.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 953 aminokiseline, а molekulska težina 106.040 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALVFQFGQP	VRAQPLPGLC	HGKLIRTNAC	DVCNSTDLPE	VEIISLLEEQ
LPHYKLRADT	IYGYDHDDWL	HTPLISPDAN	IDLTTEQIEE	TLKYFLLCAE
RVGQMTKTYN	DIDAVTRLLE	EKERDLELAA	RIGQSLLKKN	KTLTERNELL
EEQVEHIREE	VSQLRHELSM	KDELLQFYTS	AAEESEPESV	CSTPLKRNES
SSSVQNYFHL	DSLQKKLKDL	EEENVVLRSE	ASQLKTETIT	YEEKEQQLVN
DCVKELRDAN	VQIASISEEL	AKKTEDAARQ	QEEITHLLSQ	IVDLQKKAKA
CAVENEELVQ	HLGAAKDAQR	QLTAELRELE	DKYAECMEML	HEAQEELKNL
RNKTMPNTTS	RRYHSLGLFP	MDSLAAEIEG	TMRKELQLEE	AESPDITHQK
RVFETVRNIN	QVVKQRSLTP	SPMNIPGSNQ	SSAMNSLLSS	CVSTPRSSFY
GSDIGNVVLD	NKTNSIILET	EAADLGNDER	SKKPGTPGTP	GSHDLETALR
RLSLRRENYL	SERRFFEEEQ	ERKLQELAEK	GELRSGSLTP	TESIMSLGTH
SRFSEFTGFS	GMSFSSRSYL	PEKLQIVKPL	EGSATLHHWQ	QLAQPHLGGI
LDPRPGVVTK	GFRTLDVDLD	EVYCLNDFEE	DDTGDHISLP	RLATSTPVQH
PETSAHHPGK	CMSQTNSTFT	FTTCRILHPS	DELTRVTPSL	NSAPTPACGS
TSHLKSTPVA	TPCTPRRLSL	AESFTNTRES	TTTMSTSLGL	VWLLKERGIS
AAVYDPQSWD	RAGRGSLLHS	YTPKMAVIPS	TPPNSPMQTP	TSSPPSFEFK
CTSPPYDNFL	ASKPASSILR	EVREKNVRSS	ESQTDVSVSN	LNLVDKVRRF
GVAKVVNSGR	AHVPTLTEEQ	GPLLCGPPGP	APALVPRGLV	PEGLPLRCPT
VTSAIGGLQL	NSGIRRNRSF	PTMVGSSMQM	KAPVTLTSGI	LMGAKLSKQT
SLR

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182606 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032536 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
^ Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
^ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
^ "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".
^ "UniProt, Q9UPV9" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX 10.1.1.123.3574. doi:10.1167/iovs.04-1380. PMID 15851553.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182606 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032536 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10470851-5] Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.

[pmid12435728-6] Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.

[pmid16380713-7] Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.

[entrez-8] "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

[UniProt-9] "UniProt, Q9UPV9" (jezik: engleski). Pristupljeno 6. 11. 2021.

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