S Wikipedije, slobodne enciklopedije
Mitohondrijska tRNK izopenteniltransferaza jest enzim koji je kod ljudi kodiran genom TRIT1 sa hromosoma 1 .
Katalizira dodavanje izopentenil grupe iz dimetilalil-difosfata (DMAPP) na adenozinski ostatak 37 određenih molekula tRNK .[5] [6] [7]
Dužina polipeptidnog lanca je 467 aminokiselina , a molekulska težina 52.725 Da .[8]
10 20 30 40 50 MASVAAARAV PVGSGLRGLQ RTLPLVVILG ATGTGKSTLA LQLGQRLGGE IVSADSMQVY EGLDIITNKV SAQEQRICRH HMISFVDPLV TNYTVVDFRN RATALIEDIF ARDKIPIVVG GTNYYIESLL WKVLVNTKPQ EMGTEKVIDR KVELEKEDGL VLHKRLSQVD PEMAAKLHPH DKRKVARSLQ VFEETGISHS EFLHRQHTEE GGGPLGGPLK FSNPCILWLH ADQAVLDERL DKRVDDMLAA GLLEELRDFH RRYNQKNVSE NSQDYQHGIF QSIGFKEFHE YLITEGKCTL ETSNQLLKKG IEALKQVTKR YARKQNRWVK NRFLSRPGPI VPPVYGLEVS DVSKWEESVL EPALEIVQSF IQGHKPTATP IKMPYNEAEN KRSYHLCDLC DRIIIGDREW AAHIKSKSHL NQLKKRRRLD SDAVNTIESQ SVSPDHNKEP KEKGSPGQND QELKCSV
^ a b c GRCh38: Ensembl release 89: ENSG00000043514 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028653 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene . 258 (1–2): 85–93. doi :10.1016/S0378-1119(00)00421-2 . PMID 11111046 . ^ Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer" . Oncogene . 24 (35): 5502–9. doi :10.1038/sj.onc.1208687 PMID 15870694 . ^ "Entrez Gene: TRIT1 tRNA isopentenyltransferase 1" .^ "UniProt, Q9H3H1" (jezik: eng.). Pristupljeno 3. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
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