HCST
(Preusmjereno sa Transduktor signala hematopoetskih ćelija)
| HCST | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | HCST | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 604089 MGI: 1344360 HomoloGene: 8024 GeneCards: HCST | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 19: 35.9 – 35.9 Mb | Chr 7: 30.12 – 30.12 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Pretvarač signala hematopoetskih ćelija ili tranduktor signala hematopoetskih signala je protein koji je dod ljudi kodiran genom HCST.[5][6]
Ovaj gen kodira transmembranski signalni adapter koji sadrži YxxM motiv u svojoj citoplazmatskom domenu. Kodirani protein može činiti dio kompleksa receptora imunskog prepoznavanja sa receptorom sličnim lektinu C tipa NKG2D. Kao dio ovog receptorskog kompleksa, ovaj protein može aktivirati signalne puteve ovisne o fosfatidilinozitol 3-kinazi, preko svog intracitoplazmatskog motiva YxxM.
Ovaj receptorski kompleks može imati ulogu u preživljavanju i proliferaciji ćelija, aktivacijom odgovora NK i T-ćelija. Alternativna prerada rezultira u dvije varijante transkripta, koji kodiraju različite izoforme.[6]
Aminokiselinska sekvenca
[uredi | uredi izvor]- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MIHLGHILFL | LLLPVAAAQT | TPGERSSLPA | FYPGTSGSCS | GCGSLSLPLL | ||||
| AGLVAADAVA | SLLIVGAVFL | CARPRRSPAQ | EDGKVYINMP | GRG |
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000126264 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064109 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
- 1 2 "Entrez Gene: HCST hematopoietic cell signal transducer".
Dopunska literatura
[uredi | uredi izvor]- Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells". J. Immunol. 175 (12): 7819–28. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
- André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors". Eur. J. Immunol. 34 (4): 961–71. doi:10.1002/eji.200324705. PMID 15048706.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nat. Immunol. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
- Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
- Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D". Immunogenetics. 53 (3): 243–9. doi:10.1007/s002510100321. PMID 11398969. S2CID 23708388.
- Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
- Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells". J. Exp. Med. 192 (7): 1059–68. doi:10.1084/jem.192.7.1059. PMC 2193316. PMID 11015446.
- Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4. PMID 10528161.