Transrepresija

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Transrepresija je proces pri kojem jedan protein represira (tj. koči) aktivnost drugog proteina tokom interakcije protein-protein. Kada se dogodi represije između molekula dva različita proteina (intermolekulska), to se naziva trans-djelujući proces.

Supresirani protein je obično transkripcijski faktor čija je funkcija da se regulra (tj. povećava) stopu transkripcije gena. Stoga je neto rezultat transrepresije niz regulacija transkripcije gena.

Primjer transrepressijeje je sposobnost glukokortikoidnog receptora koji inhibira početak transkripcijske aktivnosti transkripcijskog faktora AP-1 i NF-kB faktora transkripcije.[1][2] In addition to transactivation, transrepression is an important pathway for the anti-inflammatory effects of glucocorticoids.[3][4] Ostali nuklearni receptori, kao što su jetreni X receptor (LXR) i Peroksisom proliferator-aktivirani receptor (PPAR) također ispoljavaju sposobnoat transrepresije drugih proteina.[5]

Reference[uredi | uredi izvor]

  1. ^ Lucibello FC, Slater EP, Jooss KU, Beato M, Müller R. "Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB". EMBO J. 9 (9): 2827–34. PMC 551994. PMID 2118106. 
  2. ^ Lin, Cw; Nakane, M; Stashko, M; Falls, D; Kuk, J; Miller, L; Huang, R; Tyree, C; Miner, Jn; Rosen, J; Kym, Pr; Coghlan, Mj; Carter, G; Lane, Bc. "trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-1benzopyrano3,4-fquinoline (A276575) and its four stereoisomers" (Free full text). Molecular Pharmacology 62 (2): 297–303. ISSN 0026-895X. PMID 12130681. doi:10.1124/mol.62.2.297. 
  3. ^ Pascual G, Glass CK (October 2006). "Nuclear receptors versus inflammation: mechanisms of transrepression". Trends Endocrinol. Metab. 17 (8): 321–7. PMID 16942889. doi:10.1016/j.tem.2006.08.005. 
  4. ^ Newton R, Holden NS (October 2007). "Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?". Mol. Pharmacol. 72 (4): 799–809. PMID 17622575. doi:10.1124/mol.107.038794. 
  5. ^ Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. "Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ". Mol. Cell 25 (1): 57–70. PMC 1850387. PMID 17218271. doi:10.1016/j.molcel.2006.11.022.