UAP1
UDP-N-acetilheksozamin pirofosforilaza je enzim koji je kod ljudi kodiran genom UAP1 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 522 aminokiseline, a molekulska težina 58.769 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MNINDLKLTL | SKAGQEHLLR | FWNELEEAQQ | VELYAELQAM | NFEELNFFFQ | ||||
| KAIEGFNQSS | HQKNVDARME | PVPREVLGSA | TRDQDQLQAW | ESEGLFQISQ | ||||
| NKVAVLLLAG | GQGTRLGVAY | PKGMYDVGLP | SRKTLFQIQA | ERILKLQQVA | ||||
| EKYYGNKCII | PWYIMTSGRT | MESTKEFFTK | HKYFGLKKEN | VIFFQQGMLP | ||||
| AMSFDGKIIL | EEKNKVSMAP | DGNGGLYRAL | AAQNIVEDME | QRGIWSIHVY | ||||
| CVDNILVKVA | DPRFIGFCIQ | KGADCGAKVV | EKTNPTEPVG | VVCRVDGVYQ | ||||
| VVEYSEISLA | TAQKRSSDGR | LLFNAGNIAN | HFFTVPFLRD | VVNVYEPQLQ | ||||
| HHVAQKKIPY | VDTQGQLIKP | DKPNGIKMEK | FVFDIFQFAK | KFVVYEVLRE | ||||
| DEFSPLKNAD | SQNGKDNPTT | ARHALMSLHH | CWVLNAGGHF | IDENGSRLPA | ||||
| IPRSATNGKS | ETITADVNHN | LKDANDVPIQ | CEISPLISYA | GEGLESYVAD | ||||
| KEFHAPLIID | ENGVHELVKN | GI |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
- ^ Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
- ^ "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".
- ^ "UniProt, Q16222" (jezik: en.). Pristupljeno 13. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura[uredi | uredi izvor]
- Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304.
- Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
- Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.