UNC5CL

UNC5CL
Identifikatori
Aliasi	UNC5CL
Vanjski ID-jevi	OMIM: 617464 MGI: 1923839 HomoloGene: 18319 GeneCards: UNC5CL
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	41,039,221 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	48,846,742 bp
Ontologija gena
Molekularna funkcija	• GO:0070122 peptidase activity; • netrin receptor activity;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • membrana;
Biološki proces	• positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of JNK cascade; • GO:0072468 Transdukcija signala; • Proteoliza; • netrin-activated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	222643
	76589
	ENSG00000124602
	ENSMUSG00000043592
	Q8IV45
	Q6R653
	NM_173561
	NM_152823
	NP_775832
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog A proteina Unc-93 (C. elegans) jest protein koji je kod ljudi kodiran genom UNC93A.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 457 aminokiselina, а molekulska težina 50.270 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDRSLRNVLV	VSFGFLLLFT	AYGGLQSLQS	SLYSEEGLGV	TALSTLYGGM
LLSSMFLPPL	LIERLGCKGT	IILSMCGYVA	FSVGNFFASW	YTLIPTSILL
GLGAAPLWSA	QCTYLTITGN	THAEKAGKRG	KDMVNQYFGI	FFLIFQSSGV
WGNLISSLVF	GQTPSQETLP	EEQLTSCGAS	DCLMATTTTN	STQRPSQQLV
YTLLGIYTGS	GVLAVLMIAA	FLQPIRDVQR	ESEGEKKSVP	FWSTLLSTFK
LYRDKRLCLL	ILLPLYSGLQ	QGFLSSEYTR	SYVTCTLGIQ	FVGYVMICFS
ATDALCSVLY	GKVSQYTGRA	VLYVLGAVTH	VSCMIALLLW	RPRADHLAVF
FVFSGLWGVA	DAVWQTQNNA	LYGVLFEKSK	EAAFANYRLW	EALGFVIAFG
YSMFLCVHVK	LYILLGVLSL	TMVAYGLVEC	VESKNPIRPH	APGQVNQAED
EEIQTKM

Funkcija[uredi | uredi izvor]

Unc93A je natporodica (MFS) i navodno rastvornih nosača kod ljudi.^[7]^[8] Pripada atipskim SLC-ovima koji su nedavno referirani.^[7] Stoga se pretpostavlja da je UNC93A transportni protein.

UNC93A je blisko povezan sa proteinima UNC93B1 i MFSD11.^[9]^[10]

Na UNC93A utiče nedostatak aminokiselina u kulturama ćelija korteksa ^[8]^[9] i izgladnjivanje u uvjetima in vivo .^[9]

Eksprimira se u neuronima, sa bojenjem blizu plazmamembrana.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124602 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043592 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
^ "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 5. 10. 2021.
^ ^a ^b Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
^ ^a ^b Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
^ ^a ^b ^c ^d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)
^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

Dopunska literatura[uredi | uredi izvor]

Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (oktobar 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124602 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043592 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Unc-93 homolog A (C. elegans)".

[UniProt-6] "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 5. 10. 2021.

[Perland_2017a-7] Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[Perland_2017b-8] Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

[Ceder_2017-9] Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)

[10] Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

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