USF1

USF1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1AN4
Identifikatori
Aliasi	USF1
Vanjski ID-jevi	OMIM: 191523 MGI: 99542 HomoloGene: 31426 GeneCards: USF1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	161,045,977 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	171,246,710 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • histone deacetylase binding; • bHLH transcription factor binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein heterodimerization activity; • vezivanje enzima; • double-stranded DNA binding; • protein kinase binding; • protein homodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • sequence-specific DNA binding; • vezivanje identičnih proteina; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• transcription regulator complex; • jedro; • NURF complex; • Set1C/COMPASS complex; • nukleoplazma;
Biološki proces	• carbon catabolite regulation of transcription; • negative regulation of fibrinolysis; • response to hypoxia; • GO:0009373 regulation of transcription, DNA-templated; • glucose homeostasis; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • late viral transcription; • transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter by glucose; • glucose metabolic process; • cellular response to insulin stimulus; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of transcription from RNA polymerase II promoter by glucose; • lipid homeostasis; • response to UV;
	Izvori:Amigo / QuickGO
Ortolozi
	7391
	22278
	ENSG00000158773
	ENSMUSG00000026641
	P22415
	Q61069
	NM_207005; NM_001276373; NM_007122
	NM_009480; NM_001305676; NM_001305677; NM_001305678
	NP_001263302; NP_009053; NP_996888
	NP_001292605; NP_001292606; NP_001292607; NP_033506
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Uzvodni stimulatorni i faktor 1 jest protein koji je kod ljudi kodiran genom USF1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 310 aminokiselina, a molekulska težina 33.538 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKGQQKTAET	EEGTVQIQEG	AVATGEDPTS	VAIASIQSAA	TFPDPNVKYV
FRTENGGQVM	YRVIQVSEGQ	LDGQTEGTGA	ISGYPATQSM	TQAVIQGAFT
SDDAVDTEGT	AAETHYTYFP	STAVGDGAGG	TTSGSTAAVV	TTQGSEALLG
QATPPGTGQF	FVMMSPQEVL	QGGSQRSIAP	RTHPYSPKSE	APRTTRDEKR
RAQHNEVERR	RRDKINNWIV	QLSKIIPDCS	MESTKSGQSK	GGILSKACDY
IQELRQSNHR	LSEELQGLDQ	LQLDNDVLRQ	QVEDLKNKNL	LLRAQLRHHG
LEVVIKNDSN

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana porodice bazni heliks-petlja-heliks leucinskih zatvarača i može funkcionirati kao ćelijski transkripcijski faktor. Kodirani protein može aktivirati transkripciju preko inicijatorskog (Inr) elementa i E-kutijskog motiva bogatih pirimidinom. Ovaj gen je povezan sa porodičnom kombinovanom hiperlipidemijom (FCHL). Za ovaj gen identificirane su dvije varijante transkripta koje kodiraju različite izoforme su.^[6]

Studija na miševima je pokazala da smanjeni nivoi USF1 povećavaju metabolizam smeđe masti.^[8]

Interakcije[uredi | uredi izvor]

Pokazano je da USF1 (ljudski gen) ima interakscije sa USF2,^[9]^[10] FOSL1,^[11] I GTF2I.^[12]^[13]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158773 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026641 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.
^ ^a ^b "Entrez Gene: USF1 upstream transcription factor 1".
^ "UniProt, P22415" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196. S2CID 24737539.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
^ Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (maj 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
^ Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
^ Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. Bibcode:1991Natur.354..245R. doi:10.1038/354245a0. PMID 1961251. S2CID 4260885.

Dopunska literatura[uredi | uredi izvor]

Corre S, Galibert MD (Jan 2006). "[USF as a key regulatory element of gene expression]" (PDF). Médecine/Sciences. 22 (1): 62–7. doi:10.1051/medsci/200622162. PMID 16386222.
Lee JC, Lusis AJ, Pajukanta P (Apr 2006). "Familial combined hyperlipidemia: upstream transcription factor 1 and beyond". Current Opinion in Lipidology. 17 (2): 101–9. doi:10.1097/01.mol.0000217890.54875.13. PMID 16531745. S2CID 20122462.
Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. Bibcode:1991Natur.354..245R. doi:10.1038/354245a0. PMID 1961251. S2CID 4260885.
Gregor PD, Sawadogo M, Roeder RG (Oct 1990). "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer". Genes & Development. 4 (10): 1730–40. doi:10.1101/gad.4.10.1730. PMID 2249772.
Henrion AA, Martinez A, Mattei MG, Kahn A, Raymondjean M (Jan 1995). "Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse". Genomics. 25 (1): 36–43. doi:10.1016/0888-7543(95)80107-W. PMID 7774954.
Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK (Jan 1994). "Structure and function of the b/HLH/Z domain of USF". The EMBO Journal. 13 (1): 180–9. doi:10.1002/j.1460-2075.1994.tb06247.x. PMC 394791. PMID 8306960.
Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
Ghosh AK, Datta PK, Jacob ST (Feb 1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (maj 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
Pajukanta P, Nuotio I, Terwilliger JD, Porkka KV, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen AC, Lehtimäki T, Viikari JS, Laakso M, Taskinen MR, Ehnholm C, Peltonen L (Apr 1998). "Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23". Nature Genetics. 18 (4): 369–73. doi:10.1038/ng0498-369. PMID 9537421. S2CID 5905269.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (Jul 2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176.
Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM (Apr 2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis. 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912. S2CID 12132097.
Coulson JM, Edgson JL, Marshall-Jones ZV, Mulgrew R, Quinn JP, Woll PJ (Feb 2003). "Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box". The Biochemical Journal. 369 (Pt 3): 549–61. doi:10.1042/BJ20021176. PMC 1223122. PMID 12403649.
Salero E, Giménez C, Zafra F (Mar 2003). "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene". The Biochemical Journal. 370 (Pt 3): 979–86. doi:10.1042/BJ20021142. PMC 1223214. PMID 12444925.
Pickwell GV, Shih H, Quattrochi LC (Apr 2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology. 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158773 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026641 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8486371-5] Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.

[entrez-6] "Entrez Gene: USF1 upstream transcription factor 1".

[UniProt-7] "UniProt, P22415" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid26819196-8] Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196. S2CID 24737539.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid8576131-10] Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.

[pmid9160889-11] Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (maj 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.

[pmid9384587-12] Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.

[pmid1961251-13] Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. Bibcode:1991Natur.354..245R. doi:10.1038/354245a0. PMID 1961251. S2CID 4260885.

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