VANGL2

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VANGL2
Identifikatori
AliasiVANGL2
Vanjski ID-jeviOMIM: 600533 MGI: 2135272 HomoloGene: 62161 GeneCards: VANGL2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za VANGL2
Genomska lokacija za VANGL2
Bend1q23.2Početak160,400,564 bp[1]
Kraj160,428,670 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za VANGL2
Genomska lokacija za VANGL2
Bend1 H3|1 79.54 cMPočetak171,828,527 bp[2]
Kraj171,856,011 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 protein binding
Ćelijska komponenta integral component of membrane
lateral plasma membrane
membrana
cell-cell junction
Ćelijska membrana
cell pole
stress fiber
basolateral plasma membrane
apical plasma membrane
COPII-coated ER to Golgi transport vesicle
cell periphery
Biološki proces hair follicle development
dopaminergic neuron axon guidance
cochlea development
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
non-canonical Wnt signaling pathway
regulation of establishment of planar polarity
lateral sprouting involved in lung morphogenesis
inner ear receptor cell stereocilium organization
regulation of actin cytoskeleton organization
somatic stem cell population maintenance
convergent extension involved in axis elongation
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
positive regulation of JUN kinase activity
muscular septum morphogenesis
serotonergic neuron axon guidance
establishment of planar polarity
membranous septum morphogenesis
somatic stem cell division
planar cell polarity pathway involved in heart morphogenesis
heparan sulfate proteoglycan biosynthetic process
Zarastanje rana
glomerulus development
establishment of body hair planar orientation
planar cell polarity pathway involved in axis elongation
establishment of planar polarity involved in neural tube closure
planar cell polarity pathway involved in neural tube closure
multicellular organism development
heart looping
Wnt signaling pathway, planar cell polarity pathway
regulation of Wnt signaling pathway
neural tube closure
inner ear receptor cell development
cochlea morphogenesis
apical protein localization
Rho protein signal transduction
establishment or maintenance of epithelial cell apical/basal polarity
kidney morphogenesis
cell migration involved in kidney development
post-anal tail morphogenesis
convergent extension involved in neural plate elongation
convergent extension involved in organogenesis
anterior/posterior pattern specification
digestive tract morphogenesis
planar cell polarity pathway involved in axon guidance
non-motile cilium assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_020335

NM_033509

RefSeq (bjelančevina)

NP_065068

NP_277044

Lokacija (UCSC)Chr 1: 160.4 – 160.43 MbChr 1: 171.83 – 171.86 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

VANGL protein planarne polarnolsti ćelije 2 jest protein koji je kod ljudi kodiran genom VANGL2 sa hromosoma 1.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 521 aminokiselina, a molekulska težina 59.714 Da.[6]

1020304050
MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGGRGDKSVTIQAPG
EPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVP
LDCSRHLGVAAGATLALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFI
SVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVVSYWLFY
GVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKV
VRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAK
KVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHER
RVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMAR
AMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQY
HKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLS
EEFVDPKSHKFVMRLQSETSV

Funkcija[uredi | uredi izvor]

Protein kodiran genom VANGL2 je membranski protein uključen u regulaciju planarne polarnosti ćelije, posebno u stereocilijskim snopićima kohleje. Kodirani protein prenosi usmjerene signale do pojedinačnih ćelija ili grupa ćelija u epitelnim listoviva. Ovaj protein je takođe uključen u razvoj nervne ploče (obezbedio RefSeq, Sep 2011).

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162738 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026556 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: VANGL planar cell polarity protein 2". Pristupljeno 5. 7. 2018.
  6. ^ "UniProt, Q9ULK5" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.