YIPF6

YIPF6
Identifikatori
Aliasi	YIPF6
Vanjski ID-jevi	OMIM: 300996 MGI: 1925179 HomoloGene: 15501 GeneCards: YIPF6
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	68,537,282 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	97,992,623 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina;
Ćelijska komponenta	• integral component of membrane; • COPII-coated ER to Golgi transport vesicle; • cis-Golgi network; • Endoplazmatski retikulum; • membrana; • Golgi trans cisterna; • Golgi medial cisterna; • trans-Golđijeva mreža; • Golđijeva membrana; • Golđijev aparat;
Biološki proces	• intestinal epithelial cell development;
	Izvori:Amigo / QuickGO
Ortolozi
	286451
	77929
	ENSG00000181704
	ENSMUSG00000047694
	Q96EC8
	Q8BR70
	NM_001195214; NM_173834
	NM_207633; NM_030007
	NP_001182143; NP_776195
	NP_997516
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein YIPF6 je protein koji je kod ljudi kodiran genom YIPF6.^[5]^[6]

Kod miševa je utvrđeno da nulti alel YIPF6 uzrokuje upalu crijeva koja rezultira spontanim kolitisom i ileitisom, oštećujući crijevnu homeostazu. Oštećenje je nastalo zbog defekata u formiranju i lučenju velikih sekrecijskih granula iz peharastih i Panethovih ćelija.^[7] Budući da je mutacija YIPF6 X-spolno vezana rezultirala spontanom bolešću, sugerira se da može povećati osjetljivost na upalnu bolest crijeva kod ljudi, posebno kod muškaraca.^[7]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181704 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047694 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: YIPF6 Yip1 domain family, member 6".
^ ^a ^b Brandl, Katherina; Tomisato, Wataru; Li, Xiaohong; et al. (juli 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences. 109 (31): 12650–12655. doi:10.1073/pnas.1210366109. PMC 3412000. PMID 22802641.
^ Moresco, Eva Marie Y.; Brandl, Katherina (januar 2013). "Linking membrane trafficking and intestinal homeostasis". Tissue Barriers. 1 (1): e23119. doi:10.4161/tisb.23119. PMC 3875636. PMID 24665373.

Dopunska literatura[uredi | uredi izvor]

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC; Wellenreuther R; Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S; Arlt D; Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT; Grafham DV; Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–337. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Mehrle A; Rosenfelder H; Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181704 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047694 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: YIPF6 Yip1 domain family, member 6".

[pnas109-7] Brandl, Katherina; Tomisato, Wataru; Li, Xiaohong; et al. (juli 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences. 109 (31): 12650–12655. doi:10.1073/pnas.1210366109. PMC 3412000. PMID 22802641.

[8] Moresco, Eva Marie Y.; Brandl, Katherina (januar 2013). "Linking membrane trafficking and intestinal homeostasis". Tissue Barriers. 1 (1): e23119. doi:10.4161/tisb.23119. PMC 3875636. PMID 24665373.

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