ZKSCAN5

ZKSCAN5
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2EM5, 2EMM, 2EMZ, 2EN3, 2EOM, 2EON, 2EOO, 2YSO, 2YTG
Identifikatori
Aliasi	ZKSCAN5
Vanjski ID-jevi	OMIM: 611272 MGI: 107533 HomoloGene: 8734 GeneCards: ZKSCAN5
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7q22.1 Početak 99,504,662 bp Kraj 99,534,700 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 G2 Početak 145,141,372 bp Kraj 145,158,560 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona cinka • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23660	22757
Ensembl	ENSG00000196652	ENSMUSG00000055991
UniProt	Q9Y2L8	Q9Z1D8
RefSeq (mRNK)	NM_014569 NM_145102 NM_001318082 NM_001318083 NM_001318084	NM_001167944 NM_016683 NM_001359187 NM_001359188 NM_001359189 NM_001359190 NM_001359191 NM_001359192
RefSeq (bjelančevina)	NP_001305011 NP_001305012 NP_001305013 NP_055384 NP_659570	NP_001161416 NP_057892 NP_001346116 NP_001346117 NP_001346118 NP_001346119 NP_001346120 NP_001346121
Lokacija (UCSC)	Chr 7: 99.5 – 99.53 Mb	Chr 5: 145.14 – 145.16 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein cinkovog prsta sa KRAB i SCAN domenom 5 jest protein koji je kod ljudi kodiran genom ZKSCAN5.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 839 aminokiselina, а molekulska težina 969.03 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MIMTESREVI		DLDPPAETSQ		EQEDLFIVKV		EEEDCTWMQE		YNPPTFETFY
QRFRHFQYHE		ASGPREALSQ		LRVLCCEWLR		PELHTKEQIL		ELLVLEQFLT
ILPEEFQPWV		REHHPESGEE		AVAVIENIQR		ELEERRQQIV		ACPDVLPRKM
ATPGAVQESC		SPHPLTVDTQ		PEQAPQKPRL		LEENALPVLQ		VPSLPLKDSQ
ELTASLLSTG		SQKLVKIEEV		ADVAVSFILE		EWGHLDQSQK		SLYRDDRKEN
YGSITSMGYE		SRDNMELIVK		QISDDSESHW		VAPEHTERSV		PQDPDFAEVS
DLKGMVQRWQ		VNPTVGKSRQ		NPSQKRDLDA		ITDISPKQST		HGERGHRCSD
CGKFFLQASN		FIQHRRIHTG		EKPFKCGECG		KSYNQRVHLT		QHQRVHTGEK
PYKCQVCGKA		FRVSSHLVQH		HSVHSGERPY		GCNECGKNFG		RHSHLIEHLK
RHFREKSQRC		SDKRSKNTKL		SVKKKISEYS		EADMELSGKT		QRNVSQVQDF
GEGCEFQGKL		DRKQGIPMKE		ILGQPSSKRM		NYSEVPYVHK		KSSTGERPHK
CNECGKSFIQ		SAHLIQHQRI		HTGEKPFRCE		ECGKSYNQRV		HLTQHQRVHT
GEKPYTCPLC		GKAFRVRSHL		VQHQSVHSGE		RPFKCNECGK		GFGRRSHLAG
HLRLHSREKS		HQCRECGEIF		FQYVSLIEHQ		VLHMGQKNEK		NGICEEAYSW
NLTVIEDKKI		ELQEQPYQCD		ICGKAFGYSS		DLIQHYRTHT		AEKPYQCDIC
RENVGQCSHT		KQHQKIYSST		KSHQCHECGR		GFTLKSHLNQ		HQRIHTGEKP
FQCKECGMNF		SWSCSLFKHL		RSHERTDPIN		TLSVEGSLL

Funkcija

Ovaj gen kodira protein cinkovog prsta iz porodice Krüppel. Protein sadrži SCAN kutiju i domen KRAB. Sličan protein kod miševa različito se eksprimira u spermatogenezi. Opisane su dvije varijante transkripta alternativne prerade koje se razlikuju samo u pet osnovnih neprevedenih regija (5' UTR). Pronađene su dodatne varijante, ali pune dužine njihove sekvence u nisu utvrđene.

Dopunska literatura

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.