ZNF182

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ZNF182
Identifikatori
AliasiZNF182
Vanjski ID-jeviOMIM: 314993 MGI: 2442220 HomoloGene: 45884 GeneCards: ZNF182
Lokacija gena (čovjek)
Hromosom X
Hrom.Hromosom X[1]
Hromosom X
Genomska lokacija za ZNF182
Genomska lokacija za ZNF182
BendXp11.23Početak47,974,851 bp[1]
Kraj48,003,989 bp[1]
Lokacija gena (miš)
Hromosom X (miš)
Hrom.Hromosom X (miš)[2]
Hromosom X (miš)
Genomska lokacija za ZNF182
Genomska lokacija za ZNF182
BendX|X A1.3Početak21,028,939 bp[2]
Kraj21,062,316 bp[2]
Ontologija gena
Molekularna funkcija GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
DNA binding
metal ion binding
nucleic acid binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta intracellular anatomical structure
Jedro
Biološki proces regulation of transcription, DNA-templated
transcription, DNA-templated
regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_006962
NM_001007088
NM_001178099

NM_001013387
NM_001111076

RefSeq (bjelančevina)

NP_001007089
NP_001171570
NP_008893

NP_001013405
NP_001104546

Lokacija (UCSC)Chr X: 47.97 – 48 MbChr X: 21.03 – 21.06 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein cinkovog prsta 182 jest protein koji je kod ljudi kodiran genom ZNF182.[5][6][7][8]

Modelni organizmi[uredi | uredi izvor]

U proučavanju funkcije ZNF182 korišteni su modelni organizmi. Uvjetna linija nokaut miša zvana Zfp182tm1b(KOMP) Wtsi generirana je u Wellcome Trust Sanger Institute.[9] Kako bi se utvrdili efekti delecije, muške i ženske životinje prolazile su standardizirano fenotipski snimanje[10][11][12][13][14] Izvršeni su dodatni pregledi: Dubinsko imunosko fenotipiziranje [15] – dubinskim fenotipiziranjem kostiju i hrskavice.[16]

Zfp182 fenotip nokaut-miša
Svojstvo Fenotip
Svi podaci raspoloživi na linkuAll data available at.[10][15][16]
Leukociti periferne krvi od 6 sedmica Normalni
Hematologija 6 sedmica Normalna
Insulin Normalan
Homozigotna varijabilnost P14 Normalna
Homozigotna plodnost Normalna
Tjelesna težina Normalna
Nervni snimak Normalan
Snaga prianjanja Normalna
Dismorfologija Normalna
Indirektna kalorimetrija Normalna
Test tolerancije glukoze Normalan
Slušni odgovor moždanog debla Normalan
DEXA-a Normalna
Radiografija Normalna
Morfologija oka Normalna
Klinička hemija Normalna
Hematologija 16 sedmica Normalna
Leukociti periferne krvi 16 sedmica Normalni
Težina srca Normalna
Infekcija bakterijom Salmonella Normalna
Citotoksična funkcija T-ćelija Normalna
Imunofenotipizacija slezene Normalna
Imunofenotipizacija mezenterskih limfnih čvorova Normalni
Imunofenotipizacija koštane srži Normalna
Epidermni imunski sastav Normalan
Izazov gripe Normalan
Izazov Trichuris-a Normalan

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147118 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054737 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Knight JC, Grimaldi G, Thiesen HJ, Bech-Hansen NT, Fletcher CD, Coleman MP (maj 1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
  6. ^ Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
  7. ^ Wang R, Cukerman E, Heng HH, Liew CC (maj 1996). "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics. 22 (3): 237–9. doi:10.1007/BF02369914. PMID 8914609.
  8. ^ "Entrez Gene: ZNF182 zinc finger protein 182".
  9. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  10. ^ a b "International Mouse Phenotyping Consortium".
  11. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  12. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  14. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  15. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".
  16. ^ a b "Potrošnja OBCD".

Dopunska literatura[uredi | uredi izvor]

  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.