ZNF347

ZNF347
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2EMA, 2EMP, 2EN4, 2ENE, 2ENF, 2EOE, 2EOW, 2EQ0, 2EQ1, 2EQ2, 2EQ3, 2YTI, 2YTK, 2YTN, 2YTR, 2YU8
Identifikatori
Aliasi	ZNF347
Vanjski ID-jevi	HomoloGene: 136343 GeneCards: ZNF347
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	53,159,075 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	84671
	n/a
	ENSG00000197937
	n/a
	Q96SE7
	n/a
	NM_001172674; NM_001172675; NM_032584
	n/a
	NP_001166145; NP_001166146; NP_115973
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein 347 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF347.^[3]

Aminokiselinska sekvenca: Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MALTQGQVTF	RDVAIEFSQE	EWTCLDPAQR	TLYRDVMLEN	YRNLASLGIS
CFDLSIISML	EQGKEPFTLE	SQVQIAGNPD	GWEWIKAVIT	ALSSEFVMKD
LLHKGKSNTG	EVFQTVMLER	QESQDIEGCS	FREVQKNTHG	LEYQCRDAEG
NYKGVLLTQE	GNLTHGRDEH	DKRDARNKLI	KNQLGLSLQS	HLPELQLFQY
EGKIYECNQV	EKSFNNNSSV	SPPQQMPYNV	KTHISKKYLK	DFISSLLLTQ
GQKANNWGSP	YKSNGCGMVF	PQNSHLASHQ	RSHTKEKPYK	CYECGKAFRT
RSNLTTHQVI	HTGEKRYKCN	ECGKVFSRNS	QLSQHQKIHT	GEKPYKCNEC
GKVFTQNSHL	VRHRGIHTGE	KPYKCNECGK	AFRARSSLAI	HQATHSGEKP
YKCNECGKVF	TQNSHLTNHW	RIHTGEKPYK	CNECGKAFGV	RSSLAIHLVI
HTGEKPYKCH	ECGKVFRRNS	HLARHQLIHT	GEKPYKCNEC	GKAFRAHSNL
TTHQVIHTGE	KPYKCNECGK	VFTQNSHLAN	HQRIHTGVKP	YMCNECGKAF
SVYSSLTTHQ	VIHTGEKPYK	CNECGKVFTQ	NSHLARHRGI	HTGEKPYKCN
ECGKVFRHNS	YLSRHQRIHT	GEKPYKYNEY	GKAFSEHSNL	TTHQVIHTGE
KPYKCNECGK	VFTQNSHLAR	HRRVHTGGKP	YQCNECGKAF	SQTSKLARHQ
RVHTGEKPYE	CNQCGKAFSV	RSSLTTHQAI	HTGKKPYKCN	ECGKVFTQNS
HLARHRGIHT	GEKPYKCNEC	GKAFSQTSKL	ARHQRIHTGE	KPYECGKPFS
ICSSLTTHQT	IHTGGKPYKC	NVWKVLKSEF	KPCKPSQNS

Interakcije[uredi | uredi izvor]

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju. Pogledajte ZFP93 (MIM 604749) za dodatne informacije o proteinima cinkovih prstiju, prema OMIM-u.^[3]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197937 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Zinc finger protein 347". Pristupljeno 1. 2. 2016.

Dopunska literatura[uredi | uredi izvor]

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Meiboom M, Murua Escobar H, Winkler S, et al. (2004). "Molecular characterization and mapping of the canine KRAB zinc finger gene ZNF331". Anim. Genet. 35 (3): 262–3. doi:10.1111/j.1365-2052.2004.01146.x. PMID 15147412.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Meiboom M, Murua Escobar H, Pentimalli F, et al. (2003). "A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas". Cytogenet. Genome Res. 101 (2): 113–7. doi:10.1159/000074165. PMID 14610350. S2CID 22276378.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wu H, Zhang S, Qiu W, et al. (2001). "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463". Biochim. Biophys. Acta. 1518 (1–2): 190–3. doi:10.1016/s0167-4781(01)00172-5. PMID 11267678.
Rippe V, Belge G, Meiboom M, et al. (2000). "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors". Genes Chromosomes Cancer. 26 (3): 229–36. doi:10.1002/(SICI)1098-2264(199911)26:3<229::AID-GCC7>3.0.CO;2-J. PMID 10502321.

Vanjski linkovi[uredi | uredi izvor]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Zinc finger protein 347

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197937 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Zinc finger protein 347". Pristupljeno 1. 2. 2016.

[1]

[2]

[3]