ZNF521
Cinkoprstni protein 521 je protein koji je kod ljudi kodiran genom ZNF521.[5]
Dužina polipeptidnog lanca je 1.311 aminokiselina, sa molekulskom težinom od 147.866.[6]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSRRKQAKPR | SLKDPNCKLE | DKTEDGEALD | CKKRPEDGEE | LEDEAVHSCD | ||||
| SCLQVFESLS | DITEHKINQC | QLTDGVDVED | DPTCSWPASS | PSSKDQTSPS | ||||
| HGEGCDFGEE | EGGPGLPYPC | QFCDKSFSRL | SYLKHHEQSH | SDKLPFKCTY | ||||
| CSRLFKHKRS | RDRHIKLHTG | DKKYHCSECD | AAFSRSDHLK | IHLKTHTSNK | ||||
| PYKCAICRRG | FLSSSSLHGH | MQVHERNKDG | SQSGSRMEDW | KMKDTQKCSQ | ||||
| CEEGFDFPED | LQKHIAECHP | ECSPNEDRAA | LQCVYCHELF | VEETSLMNHM | ||||
| EQVHSGEKKN | SCSICSESFH | TVEELYSHMD | SHQQPESCNH | SNSPSLVTVG | ||||
| YTSVSSTTPD | SNLSVDSSTM | VEAAPPIPKS | RGRKRAAQQT | PDMTGPSSKQ | ||||
| AKVTYSCIYC | NKQLFSSLAV | LQIHLKTMHL | DKPEQAHICQ | YCLEVLPSLY | ||||
| NLNEHLKQVH | EAQDPGLIVS | AMPAIVYQCN | FCSEVVNDLN | TLQEHIRCSH | ||||
| GFANPAAKDS | NAFFCPHCYM | GFLTDSSLEE | HIRQVHCDLS | GSRFGSPVLG | ||||
| TPKEPVVEVY | SCSYCTNSPI | FNSVLKLNKH | IKENHKNIPL | ALNYIHNGKK | ||||
| SRALSPLSPV | AIEQTSLKMM | QAVGGAPARP | TGEYICNQCG | AKYTSLDSFQ | ||||
| THLKTHLDTV | LPKLTCPQCN | KEFPNQESLL | KHVTIHFMIT | STYYICESCD | ||||
| KQFTSVDDLQ | KHLLDMHTFV | FFRCTLCQEV | FDSKVSIQLH | LAVKHSNEKK | ||||
| VYRCTSCNWD | FRNETDLQLH | VKHNHLENQG | KVHKCIFCGE | SFGTEVELQC | ||||
| HITTHSKKYN | CKFCSKAFHA | IILLEKHLRE | KHCVFETKTP | NCGTNGASEQ | ||||
| VQKEEVELQT | LLTNSQESHN | SHDGSEEDVD | TSEPMYGCDI | CGAAYTMETL | ||||
| LQNHQLRDHN | IRPGESAIVK | KKAELIKGNY | KCNVCSRTFF | SENGLREHMQ | ||||
| THLGPVKHYM | CPICGERFPS | LLTLTEHKVT | HSKSLDTGNC | RICKMPLQSE | ||||
| EEFLEHCQMH | PDLRNSLTGF | RCVVCMQTVT | STLELKIHGT | FHMQKTGNGS | ||||
| AVQTTGRGQH | VQKLYKCASC | LKEFRSKQDL | VKLDINGLPY | GLCAGCVNLS | ||||
| KSASPGINVP | PGTNRPGLGQ | NENLSAIEGK | GKVGGLKTRC | SSCNVKFESE | ||||
| SELQNHIQTI | HRELVPDSNS | TQLKTPQVSP | MPRISPSQSD | EKKTYQCIKC | ||||
| QMVFYNEWDI | QVHVANHMID | EGLNHECKLC | SQTFDSPAKL | QCHLIEHSFE | ||||
| GMGGTFKCPV | CFTVFVQANK | LQQHIFSAHG | QEDKIYDCTQ | CPQKFFFQTE | ||||
| LQNHTMTQHS | S |
Funkcija[uredi | uredi izvor]
Proteini cinkovog prsta vežu nukleinske kiseline i imaju važnu ulogu u različitim ćelijskim funkcijama, uključujući proliferacija ćelija, diferencijacija i apoptozu. Ovaj gen kodira protein cinkovog prsta i pripada porodici proteina cinka-prsta tipa Krüppel C2H2. Može biti uključen u proces transkripcije.
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198795 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024420 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Zinc finger protein 521".
- ^ "UniProt, Q96K83". Pristupljeno September 12, 2017.
Dopunska literatura[uredi | uredi izvor]
- La Rocca R, Fulciniti M, Lakshmikanth T, Mesuraca M, Ali TH, Mazzei V, Amodio N, Catalano L, Rotoli B, Ouerfelli O, Grieco M, Gulletta E, Bond HM, Morrone G, Ferrone S, Carbone E (april 2009). "Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells". Journal of Immunology. 182 (8): 4529–37. doi:10.4049/jimmunol.0802109. PMC 2747523. PMID 19342626.
- Bond HM, Mesuraca M, Amodio N, Mega T, Agosti V, Fanello D, Pelaggi D, Bullinger L, Grieco M, Moore MA, Venuta S, Morrone G (2008). "Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells". The International Journal of Biochemistry & Cell Biology. 40 (5): 848–54. doi:10.1016/j.biocel.2007.04.006. PMID 17543573.
- Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG (mart 2003). "Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein". Blood. 101 (5): 1934–40. doi:10.1182/blood-2002-08-2652. PMID 12393497.
- Matsubara E, Sakai I, Yamanouchi J, Fujiwara H, Yakushijin Y, Hato T, Shigemoto K, Yasukawa M (februar 2009). "The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation". The Journal of Biological Chemistry. 284 (6): 3480–7. doi:10.1074/jbc.M805874200. PMID 19049973.
- Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (mart 2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
- McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, O'Conner GD, Kasperavičiūtė D, Radtke RA, Heinzen EL, Sisodiya SM, Delanty N, Cavalleri GL (mart 2012). "Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions". Pharmacogenomics. 13 (4): 399–405. doi:10.2217/pgs.11.165. PMC 3428903. PMID 22379998.
- Hesse E, Kiviranta R, Wu M, Saito H, Yamana K, Correa D, Atfi A, Baron R (mart 2010). "Zinc finger protein 521, a new player in bone formation". Annals of the New York Academy of Sciences. 1192: 32–7. doi:10.1111/j.1749-6632.2009.05347.x. PMID 20392215. S2CID 29853724.
- Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (januar 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/BF03402003. PMC 2039936. PMID 11984006.
- Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D, Mesuraca M, Pazzaglia S, Semenkow S, Bar EE, Kool M, Pfister S, Bond HM, Eberhart CG, Steinkühler C, Morrone G (august 2013). "Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells". Oncotarget. 4 (8): 1280–92. doi:10.18632/oncotarget.1176. PMC 3787157. PMID 23907569.