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ZNF737 Identifikatori Aliasi ZNF737 Vanjski ID-jevi OMIM : 603984 HomoloGene : 130014 GeneCards : ZNF737 Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi Vrste Čovjek Miš Entrez Ensembl UniProt RefSeq (mRNK) RefSeq (bjelančevina) Lokacija (UCSC) Chr 19: 20.54 – 20.57 Mb n/a PubMed pretraga[2] n/a Wikipodaci
Protein cinkovog prsta 737 je protein koji je kod ljudi kodiran genom ZNF737 .[3]
Aminokiselinska sekvenca
Simboli
10 20 30 40 50 MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYRNL VFLGIVVSKP DLITCLEQGK KPLTMKKHEM VANPSVTCSH FARDLWPEQS IKDSFQKVTL RRYENYGHDN LQFKKGCESV DECKVHKRGY NGLNQYLTTT QSKIFQCDKY VKVIHKFSNS NRHKIRHTGK KPFKCIECGK AFNQSSTLTT HKKIHTGEKP FKCEECGKAF NWSSHLTTHK RIHTGEKRYK CEDCGKAFSR FSYLTAHKII HSGEKPYKCE ECGKAFKRSS NLTTHKIIHT GEKPYKCEEC GKAFKRSSIL TAHKIIHSGE KPYKCEECGK AFKHPSVLTT HKRIHTGEKP YKCEECGRAF KYFSSLTTHK IIHSGEKPYK CEECGKAFNW SSHLTTHKRI HTGEKPYKCE ECGEAFKYSS SLTTHKIIHT GQQPFKCEEC GKAFKCFSIL TTHKRIHTGE KPYKCEECGK AFNSSSHLTA HKRIHTGEKP YKCERCGKAF KRSFILTRHK RIHTGEKPYK CEECGKGFKC PSTLTTHKVI HTGEKL
Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina , koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[3]
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. doi :10.1038/nature02399 PMID 15057824 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Mataki C, Murakami T, Umetani M, et al. (2001). "A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha" . J. Atheroscler. Thromb . 7 (2): 97–103. doi :10.5551/jat1994.7.97 PMID 11426589 . Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins" . Proc. Natl. Acad. Sci. U.S.A . 88 (21): 9563–7. doi :10.1073/pnas.88.21.9563 . PMC 52758 PMID 1946370 . Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics . 13 (4): 999–1007. doi :10.1016/0888-7543(92)90013-I . PMID 1505991 .
