ZNF737

ZNF737
Identifikatori
Aliasi	ZNF737
Vanjski ID-jevi	OMIM: 603984 HomoloGene: 130014 GeneCards: ZNF737
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19p12 Početak 20,535,825 bp Kraj 20,565,809 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	100129842	n/a
Ensembl	ENSG00000237440	n/a
UniProt	O75373	n/a
RefSeq (mRNK)	NM_001159293	n/a
RefSeq (bjelančevina)	NP_001152765	n/a
Lokacija (UCSC)	Chr 19: 20.54 – 20.57 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Protein cinkovog prsta 737 je protein koji je kod ljudi kodiran genom ZNF737.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGPLQFRDVA		IEFSLEEWHC		LDTAQRNLYR		NVMLENYRNL		VFLGIVVSKP
DLITCLEQGK		KPLTMKKHEM		VANPSVTCSH		FARDLWPEQS		IKDSFQKVTL
RRYENYGHDN		LQFKKGCESV		DECKVHKRGY		NGLNQYLTTT		QSKIFQCDKY
VKVIHKFSNS		NRHKIRHTGK		KPFKCIECGK		AFNQSSTLTT		HKKIHTGEKP
FKCEECGKAF		NWSSHLTTHK		RIHTGEKRYK		CEDCGKAFSR		FSYLTAHKII
HSGEKPYKCE		ECGKAFKRSS		NLTTHKIIHT		GEKPYKCEEC		GKAFKRSSIL
TAHKIIHSGE		KPYKCEECGK		AFKHPSVLTT		HKRIHTGEKP		YKCEECGRAF
KYFSSLTTHK		IIHSGEKPYK		CEECGKAFNW		SSHLTTHKRI		HTGEKPYKCE
ECGEAFKYSS		SLTTHKIIHT		GQQPFKCEEC		GKAFKCFSIL		TTHKRIHTGE
KPYKCEECGK		AFNSSSHLTA		HKRIHTGEKP		YKCERCGKAF		KRSFILTRHK
RIHTGEKPYK		CEECGKGFKC		PSTLTTHKVI		HTGEKL

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mataki C, Murakami T, Umetani M, et al. (2001). "A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha". J. Atheroscler. Thromb. 7 (2): 97–103. doi:10.5551/jat1994.7.97. PMID 11426589.
• Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
• Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.