PHF2

PHF2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifikatori
Aliasi	PHF2
Vanjski ID-jevi	OMIM: 604351 MGI: 1338034 HomoloGene: 3934 GeneCards: PHF2
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	93,679,587 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	49,024,595 bp
Ontologija gena
Molekularna funkcija	• iron ion binding; • histone H3-methyl-lysine-9 demethylase activity; • GO:0001105 transcription coactivator activity; • dioxygenase activity; • vezivanje iona metala; • methylated histone binding; • GO:0001948, GO:0016582 vezivanje za proteine; • oxidoreductase activity; • histone demethylase activity; • vezivanje iona cinka;
Ćelijska komponenta	• nukleoplazma; • hromosom; • Jedarce; • Primarno suženje; • kinetohor; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • histone H3-K9 demethylation; • protein demethylation; • transcription, DNA-templated; • negative regulation of ribosomal DNA heterochromatin assembly; • liver development; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	5253
	18676
	ENSG00000197724
	ENSMUSG00000038025
	O75151
	Q9WTU0
	NM_005392; NM_024517
	NM_011078
	NP_005383
	NP_035208
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein PHD-prsta 2 je protein koji je kod ljudi kodiran genom PHF2.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.096 aminokiselina, а molekulska težina Da. 120 775^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATVPVYCVC	RLPYDVTRFM	IECDACKDWF	HGSCVGVEEE	EAPDIDIYHC
PNCEKTHGKS	TLKKKRTWHK	HGPGQAPDVK	PVQNGSQLFI	KELRSRTFPS
AEDVVARVPG	SQLTLGYMEE	HGFTEPILVP	KKDGLGLAVP	APTFYVSDVE
NYVGPERSVD	VTDVTKQKDC	KMKLKEFVDY	YYSTNRKRVL	NVTNLEFSDT
RMSSFVEPPD	IVKKLSWVEN	YWPDDALLAK	PKVTKYCLIC	VKDSYTDFHI
DSGGASAWYH	VLKGEKTFYL	IRPASANISL	YERWRSASNH	SEMFFADQVD
KCYKCIVKQG	QTLFIPSGWI	YATLTPVDCL	AFAGHFLHSL	SVEMQMRAYE
VERRLKLGSL	TQFPNFETAC	WYMGKHLLEA	FKGSHKSGKQ	LPPHLVQGAK
ILNGAFRSWT	KKQALAEHED	ELPEHFKPSQ	LIKDLAKEIR	LSENASKAVR
PEVNTVASSD	EVCDGDREKE	EPPSPIEATP	PQSLLEKVSK	KKTPKTVKMP
KPSKIPKPPK	PPKPPRPPKT	LKLKDGGKKK	GKKSRESASP	TIPNLDLLEA
HTKEALTKME	PPKKGKATKS	VLSVPNKDVV	HMQNDVERLE	IREQTKSKSE
AKWKYKNSKP	DSLLKMEEEQ	KLEKSPLAGN	KDNKFSFSFS	NKKLLGSKAL
RPPTSPGVFG	ALQNFKEDKP	KPVRDEYEYV	SDDGELKIDE	FPIRRKKNAP
KRDLSFLLDK	KAVLPTPVTK	PKLDSAAYKS	DDSSDEGSLH	IDTDTKPGRN
ARVKKESGSS	AAGILDLLQA	SEEVGALEYN	PSSQPPASPS	TQEAIQGMLS
MANLQASDSC	LQTTWGAGQA	KGSSLAAHGA	RKNGGGSGKS	AGKRLLKRAA
KNSVDLDDYE	EEQDHLDACF	KDSDYVYPSL	ESDEDNPIFK	SRSKKRKGSD
DAPYSPTARV	GPSVPRQDRP	VREGTRVASI	ETGLAAAAAK	LSQQEEQKSK
KKKSAKRKLT	PNTTSPSTST	SISAGTTSTS	TTPASTTPAS	TTPASTSTAS
SQASQEGSSP	EPPPESHSSS	LADHEYTAAG	TFTGAQAGRT	SQPMAPGVFL
TQRRPSASSP	NNNTAAKGKR	TKKGMATAKQ	RLGKILKIHR	NGKLLL

Funkcija[uredi | uredi izvor]

Ovaj gen kodira protein koji sadrži prst poput cinkovog prsta PHD (biljni homeodomen), za razliku od drugih klasa motiva cinkovog prsta, te hidrofobni i visoko konzervirani domen . PHD prst prikazuje tipski aranžman Cys₄–His–Cys₃. Smatra se da geni PHD-prstiju pripadaju raznolikoj skupini transkripcijskih regulatora koji mogu uticati na ekspresiju gena eukariota, utičući na strukturu hromatina.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PHD finger protein 2". Pristupljeno 9. 4. 2016.
^ "UniProt, O75151". Pristupljeno 10. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMC 2633285. PMID 18990233.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PHD finger protein 2". Pristupljeno 9. 4. 2016.

[UniProt-6] "UniProt, O75151". Pristupljeno 10. 9. 2021.

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