RRP1

RRP1
Identifikatori
Aliasi	RRP1
Vanjski ID-jevi	OMIM: 610653 MGI: 1203500 HomoloGene: 90906 GeneCards: RRP1
Lokacija gena (čovjek)
Hrom.	Hromosom 21 (čovjek)
Kraj	43,805,293 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	78,248,877 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa RNK; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro; • Jedarce; • preribosome, small subunit precursor; • preribosome, large subunit precursor;
Biološki proces	• rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	8568
	18114
	ENSG00000160214
	ENSMUSG00000061032
	P56182
	P56183
	NM_003683
	NM_010925
	NP_003674
	NP_035055
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog A proteina 1 prerade ribosomske RNK jest protein koji je kod ljudi kodiran genom RRP1 sa hromosoma 21.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 461 aminokiselina, a molekulska težina 52.839 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVSRVQLPPE	IQLAQRLAGN	EQVTRDRAVR	KLRKYIVART	QRAAGGFTHD
ELLKVWKGLF	YCMWMQDKPL	LQEELGRTIS	QLVHAFQTTE	AQHLFLQAFW
QTMNREWTGI	DRLRLDKFYM	LMRMVLNESL	KVLKMQGWEE	RQIEELLELL
MTEILHPSSQ	APNGVKSHFI	EIFLEELTKV	GAEELTADQN	LKFIDPFCRI
AARTKDSLVL	NNITRGIFET	IVEQAPLAIE	DLLNELDTQD	EEVASDSDES
SEGGERGDAL	SQKRSEKPPA	GSICRAEPEA	GEEQAGDDRD	SGGPVLQFDY
EAVANRLFEM	ASRQSTPSQN	RKRLYKVIRK	LQDLAGGIFP	EDEIPEKACR
RLLEGRRQKK	TKKQKRLLRL	QQERGKGEKE	PPSPGMERKR	SRRRGVGADP
EARAEAGEQP	GTAERALLRD	QPRGRGQRGA	RQRRRTPRPL	TSARAKAANV
QEPEKKKKRR	E

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je pretpostavljeni homolog kvašćčeve ribosomske RNK koji obrađuje protein RRP1. Kodirani protein je uključen u kasne faze nukleologeneze na kraju mitoza i može biti potreban za stvaranje 28S rRNK.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160214 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061032 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
^ Savino TM, Bastos R, Jansen E, Hernandez-Verdun D (Aug 1999). "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis". J Cell Sci. 112. ( Pt 12) (12): 1889–900. doi:10.1242/jcs.112.12.1889. PMID 10341208.
^ ^a ^b ^c "Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence".

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Jansen E, Meulemans SM, Orlans IC, Van de Ven WJ (1997). "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3". Genomics. 42 (2): 336–41. doi:10.1006/geno.1997.4755. PMID 9192856.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604. S2CID 35369661.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160214 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061032 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10830953-5] Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.

[pmid10341208-6] Savino TM, Bastos R, Jansen E, Hernandez-Verdun D (Aug 1999). "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis". J Cell Sci. 112. ( Pt 12) (12): 1889–900. doi:10.1242/jcs.112.12.1889. PMID 10341208.

[entrez-7] "Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence".

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