FUNDC1

FUNDC1
Identifikatori
Aliasi	FUNDC1
Vanjski ID-jevi	OMIM: 300871 MGI: 1919268 HomoloGene: 41738 GeneCards: FUNDC1
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	44,542,859 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	17,438,564 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • integral component of mitochondrial outer membrane; • membrana; • mitohondrija; • mitochondrial outer membrane;
Biološki proces	• Autofagija; • response to hypoxia; • autophagy of mitochondrion; • response to organonitrogen compound; • macroautophagy;
	Izvori:Amigo / QuickGO
Ortolozi
	139341
	72018
	ENSG00000069509
	ENSMUSG00000025040
	Q8IVP5
	Q9DB70
	NM_173794
	NM_028058; NM_001313745; NM_001313746
	NP_776155
	NP_001300674; NP_001300675; NP_082334
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

FUN14 domen-sadržeći protein 1 je protein koji je kod ljudi kodiran genom that FUNDC1 .^[5]

Model organizmi[uredi | uredi izvor]

*Fundc1* fenotip nokaut miša
Obilježje	Fenotip
Homozigotna varijabilnost	Normalan
Plodnost	Normalna
Tjelesna težina	Normalna
Anksioznost	Normalna
-	Neurološka procjena	Normalna
Snaga prianjanja	Normalna
Grijna ploča	Normalna
Dismorfologoja	Normalna
Indirektna kalorimetrija	Normalna
Test tolerancije glukoze	Normalan
Slušni odgovor moždanog debla	Normalan
DEXA	Normalna
Radiografija	Normalna
Tjelesna temperatura	Normalna
Morfologija oka	Normalna
Klinička hemija	Normalna
Hematologija	Normalna
Limfociti periferne krvi	Normalni
Mikronukleus test	Normalan
Težina srca	Normalna
infekcija bakterijom Salmonella	Normalna^[6]
Infekvija bakterijom Citrobacter	Normalna^[7]
Svi testovi i analije sa linka All tests and analysis from^[8]^[9]

u proučavanju funkcije FUNDC1 korišteni su i model organizmi. Uslovna linija nokaut miševa, bila je Fundc1^{tm1a(KOMP)Wtsi},^[10]^[11] generirana kao dio programa Međunarodnog konzorcija za miševe – visokopropusnog projekta mutageneze za generiranje i distribuciju životinjskih modela bolesti zainteresiranim naučnicima – u Wellcome Trust Sanger Institute.^[12]^[13]^[14]

Muške i ženske životinje prolazile su standardizirano fenotipsko snimanje, kako bi se utvrdili učinci delecije.^[8]^[15] Nakon 22 izvedena testa na mutantnim miševima, međutim, nisu primijećene značajne abnormalnosti.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069509 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025040 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FUN14 domain containing 1". Pristupljeno 19. 9. 2011.
^ "Salmonella infection data for Fundc1". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Fundc1". Wellcome Trust Sanger Institute.
^ ^a ^b ^c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium". Arhivirano s originala, 2. 6. 2012. Pristupljeno 28. 3. 2021.
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (juni 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (januar 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Dopunska literatura[uredi | uredi izvor]

Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W. -M.; Distel, M. A.; Slagboom, E. P.; Boomsma, D. I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A. C. J. W.; Van Duijn, C. M.; Schlessinger, D.; Abecasis, G. R.; Costa Jr, P. T. (2008). "Genome-wide association scan for five major dimensions of personality". Molecular Psychiatry. 15 (6): 647–656. doi:10.1038/mp.2008.113. PMC 2874623. PMID 18957941.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069509 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025040 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FUN14 domain containing 1". Pristupljeno 19. 9. 2011.

[''Salmonella''_infection-6] "Salmonella infection data for Fundc1". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-7] "Citrobacter infection data for Fundc1". Wellcome Trust Sanger Institute.

[mgp_reference-8] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.

[9] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-10] "International Knockout Mouse Consortium". Arhivirano s originala, 2. 6. 2012. Pristupljeno 28. 3. 2021.

[mgi_allele_ref-11] "Mouse Genome Informatics".

[pmid21677750-12] Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-13] Dolgin E (juni 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-14] Collins FS, Rossant J, Wurst W (januar 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.

[pmid21722353-15] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

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