Kaspaza-14
Kaspaza-14 jest enzim koji je kod ljudi kodiran genom CASP14 sa hromosoma 19.[5][6][7]
Funkcija[uredi | uredi izvor]
Gen CASP14 kodira člana porodice cistein-aspartanih proteaza (kaspaza). Sekvencna aktivacija kaspaza ima centralnu ulogu u fazi izvršenja ćelijske apoptoze. Kaspaze postoje kao neaktivni proenzimi koji se podvrgavaju proteolitskoj obradi na konzerviranim asparaginskim ostacima kako bi se dobile dvije podjedinice, veliku i malu, koje se dimeriziraju i formiraju aktivni enzim. Pokazalo se da je ova kaspaza obrađena i aktivirana pomoću kaspaze-8 i 10 in vitro, i anti-Fas agonističkog antitijela ili TNF-ove apoptoze koja indukuje ligand in vivo. Ekspresija i obrada ove kaspaze može biti uključena u keratinocitnu terminalnu diferencijaciju, što je važno za formiranje kožne barijere.[7]
Prema Atlasu ljudskih proteina,[8] CASP14 proteinom je obogaćena ljudska koža i uglavnom je eksprimiran u gornjim slojevima epiderme. Prema Atlasu ćelija, protein je uglavnom lokalizovan u citosolu.[9]
Također pogledajte[uredi | uredi izvor]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (maj 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ. 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698.
- ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998). "Caspase-14 is a novel developmentally regulated protease". J Biol Chem. 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675.
- ^ a b "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase".
- ^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina (23. 1. 2015). "Tissue-based map of the human proteome". Science (jezik: engleski). 347 (6220): 1260419. doi:10.1126/science.1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377.
- ^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars (26. 5. 2017). "A subcellular map of the human proteome". Science (jezik: engleski). 356 (6340): eaal3321. doi:10.1126/science.aal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558.
Dopunska literatura[uredi | uredi izvor]
- Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
- Ahmad M, Srinivasula SM, Hegde R, et al. (1998). "Identification and characterization of murine caspase-14, a new member of the caspase family". Cancer Res. 58 (22): 5201–5. PMID 9823333.
- Eckhart L, Ban J, Fischer H, Tschachler E (2000). "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation". Biochem. Biophys. Res. Commun. 277 (3): 655–9. doi:10.1006/bbrc.2000.3698. PMID 11062009.
- Eckhart L, Declercq W, Ban J, et al. (2001). "Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation". J. Invest. Dermatol. 115 (6): 1148–51. doi:10.1046/j.1523-1747.2000.00205.x. PMID 11121154.
- Lippens S, Kockx M, Knaapen M, et al. (2001). "Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing". Cell Death Differ. 7 (12): 1218–24. doi:10.1038/sj.cdd.4400785. PMID 11175259.
- Pistritto G, Jost M, Srinivasula SM, et al. (2003). "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia". Cell Death Differ. 9 (9): 995–1006. doi:10.1038/sj.cdd.4401061. PMID 12181750. S2CID 23933663.
- Chien AJ, Presland RB, Kuechle MK (2002). "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation". Biochem. Biophys. Res. Commun. 296 (4): 911–7. doi:10.1016/S0006-291X(02)02015-6. PMID 12200134.
- Rendl M, Ban J, Mrass P, et al. (2003). "Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner". J. Invest. Dermatol. 119 (5): 1150–5. doi:10.1046/j.1523-1747.2002.19532.x. PMID 12445205.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lippens S, Kockx M, Denecker G, et al. (2004). "Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures". Am. J. Pathol. 165 (3): 833–41. doi:10.1016/s0002-9440(10)63346-9. PMC 1618612. PMID 15331408.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Walsh DS, Borke JL, Singh BB, et al. (2005). "Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation". J. Dermatol. Sci. 37 (1): 61–3. doi:10.1016/j.jdermsci.2004.10.003. PMID 15619438.
- Koenig U, Sommergruber W, Lippens S (2005). "Aberrant expression of caspase-14 in epithelial tumors". Biochem. Biophys. Res. Commun. 335 (2): 309–13. doi:10.1016/j.bbrc.2005.07.072. PMID 16061209.
- Krajewska M, Kim H, Shin E, et al. (2006). "Tumor-associated alterations in caspase-14 expression in epithelial malignancies". Clin. Cancer Res. 11 (15): 5462–71. doi:10.1158/1078-0432.CCR-04-2527. PMID 16061862.
- Kam DW, Charles AK, Dharmarajan AM (2005). "Caspase-14 expression in the human placenta". Reprod. Biomed. Online. 11 (2): 236–43. doi:10.1016/S1472-6483(10)60964-9. PMID 16168224.
- Park K, Kuechle MK, Choe Y, et al. (2006). "Expression and characterization of constitutively active human caspase-14". Biochem. Biophys. Res. Commun. 347 (4): 941–8. doi:10.1016/j.bbrc.2006.06.156. PMID 16854378.
- White L, Dharmarajan A, Charles A (2007). "Caspase-14: a new player in cytotrophoblast differentiation". Reprod. Biomed. Online. 14 (3): 300–7. doi:10.1016/S1472-6483(10)60871-1. PMID 17359582.
- Hsu S, Qin H, Dickinson D, et al. (2007). "Expression of caspase-14 reduces tumorigenicity of skin cancer cells". In Vivo. 21 (2): 279–83. PMID 17436577.
Vanjski linkovi[uredi | uredi izvor]
- The MEROPS online database for peptidases and their inhibitors: C14.018 Arhivirano 24. 10. 2007. na Wayback Machine