LIME1

LIME1
Identifikatori
Aliasi	LIME1
Vanjski ID-jevi	OMIM: 609809 MGI: 1919949 HomoloGene: 56785 GeneCards: LIME1
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	181,025,421 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein kinase binding;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • membrana; • Vanćelijsko; • U2-type post-mRNA release spliceosomal complex; • B cell receptor complex;
Biološki proces	• B cell receptor signaling pathway; • T cell receptor signaling pathway; • adaptive immune response; • immune system process; • spliceosomal complex disassembly; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulation of phosphatidylinositol 3-kinase signaling; • regulation of I-kappaB kinase/NF-kappaB signaling; • regulation of MAP kinase activity; • regulation of release of sequestered calcium ion into cytosol; • regulation of NIK/NF-kappaB signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	54923
	72699
	n/a
	ENSMUSG00000090077
	Q9H400
	Q9EQR5
	NM_017806; NM_001305654; NM_001305655
	NM_023684
	NP_001292583; NP_001292584; NP_060276
	NP_076173
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Lck-interaktivni transmembranski adapter 11 je protein koji je kod ljudi kodiran genom 'LIME1.^[4]^[5]

LIME1 je transmembranski fosfoproteinski adapter povezan sa splavom koji je preferencijalno eksprimiran u hemopoetskim ćelijama, posebno T-ćelija ma (Brdickova et al., 2003; Hur et al., 2003). [prema OMIM] ^[5]

Učešće u strukturama i funkcijama[uredi | uredi izvor]

Molekulska funkcija

vezanje za protein-kinazu
integralna komponenta membrane

Ćelijska komponenta

plazmamembrana
membrana
vanćelijski prostor
U2-tip splajsosomskog kompleksa koji oslobađa iRNK
Kompleks receptora B-ćelija

Biološki procesi

signalni put receptora B-ćelija
signalni put receptora T-ćelija
adaptivni imunski odgovor
proces imunskog sistema
demontaža splajsosomskog kompleksa
regulacija transkripcije RNK-polimerazom II
regulacija signalizacije fosfatidilinozitol 3-kinaze
regulacija signalizacije I-kappaB/NF-kappaB kinaze
regulacija aktivnosti MAP-kinaze
regulacija oslobađanja sekvestriranog iona kalcija u citosol
regulacija signalizacije NIK/NF-kappaB

Izvori: Amigo/QuickGO

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090077 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ ^a ^b "Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1".

Dopunska literatura[uredi | uredi izvor]

Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Hur EM, Son M, Lee OH, et al. (2004). "LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation". J. Exp. Med. 198 (10): 1463–73. doi:10.1084/jem.20030232. PMC 2194117. PMID 14610044.
Brdicková N, Brdicka T, Angelisová P, et al. (2004). "LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling". J. Exp. Med. 198 (10): 1453–62. doi:10.1084/jem.20031484. PMC 2194115. PMID 14610046.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
Ahn E, Lee H, Yun Y (2006). "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation". Blood. 107 (4): 1521–7. doi:10.1182/blood-2005-05-1859. PMID 16249387.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000090077 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-4] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-5] "Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1".

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