ZNF23

ZNF23
Identifikatori
Aliasi	ZNF23
Vanjski ID-jevi	OMIM: 194527 MGI: 2443465 HomoloGene: 27083 GeneCards: ZNF23
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	71,463,095 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	110,819,373 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7571
	234725
	ENSG00000167377
	ENSMUSG00000044676
	P17027
	n/a
	NM_145911; NM_001304492; NM_001304493; NM_001304494
	NM_175480
NP_001291421; NP_001291422; NP_001291423; NP_666016; NP_001368894;
	NP_001368895; NP_001368896; NP_001368897; NP_001368898; NP_001368899; NP_001368900; NP_001368901; NP_001368902; NP_001368903; NP_001368904; NP_001368905; NP_001368906; NP_001368907; NP_001368908; NP_001368909; NP_001368910; NP_001368913
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cinkoprstni protein 23 je protein koji j kod ljudi kodiran genom ZNF23 .^[5]

Kloniranje i ekspresija[uredi | uredi izvor]

Zhou et al. (2002) klonirali ZNF359 iz cDNK biblioteke ljudskog srca. Izvedeni protein sadrži motive KRAB A i KRAB B na N-kraju i 16 tandemski ponovljenih motiva cinkovi prstiju tipa kruppel na C-kraju. Northern blot analiza otkrila je ekspresiju transkripta od 3,2 kb u različitim tkivima odraslih, sa najvećom ekspresijom u skeletnim mišićima, srcu, jetri i gušterači. Dalje analize u embrionskim tkivima (18-23 sedmice) pokazale su razvojno specifični obrazac ekspresije u srcu, skeletnim mišićima, jetri, plućima, bubrezima i mozgu.^[6]

Mapiranje[uredi | uredi izvor]

Cannizzaro et al. (1993) mapirali su člana porodice KOX gena, ZNF23 (KOX16), na hromosomu 16, lokus q22, hibridizacijom in situ.^[7]

Mapna lokacija nalazi se u blizini dva osjetljiva mjesta, FRA16B i FRA16C. Regija 16q22 je, osim toga, uključena u hromosomske promjene karakteristične za akutnu mijeloidnu leukemiju. Gen ZNF19 nalazi se u istoj regiji. Analogni mišji geni u su na hromosomu 8 u regiji sintetske homologije. Pokusima elektroforeze u impulsnom polju, Rousseau-Merck et al. (1993) pokazali su da se geni ZNF19 i ZNF23 nalaze unutar fragmenta DNK od 200–300 kb.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167377 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044676 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ZNF23 zinc finger protein 23 (KOX 16)".
^ Zhou, L., zhu, C., Luo, K., Li, Y., Pi, H., Yuan, W., Wang, Y., Huang, C., Liu, M., Wu, X. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Biochem. Biophys. Res. Commun. 295: 862-868, 2002. PubMed: 12127974
^ Cannizzaro, L. A., Aronson, M. M., Thiesen, H. J. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Hum. Genet. 91: 383-385, 1993. PubMed: 8500793
^ Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. PubMed: 8262519

Dopunsaka literatura[uredi | uredi izvor]

Huang C, Jia Y, Yang S, et al. (2007). "Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression". Exp. Cell Res. 313 (2): 254–63. doi:10.1016/j.yexcr.2006.10.009. PMID 17137575.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhou L, Zhu C, Luo K, et al. (2002). "Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development". Biochem. Biophys. Res. Commun. 295 (4): 862–8. doi:10.1016/S0006-291X(02)00759-3. PMID 12127974.
Cannizzaro LA, Aronson MM, Thiesen HJ (1993). "Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24". Hum. Genet. 91 (4): 383–5. doi:10.1007/BF00217362. PMID 8500793. S2CID 26273171.
Abrink M, Aveskogh M, Hellman L (1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167377 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044676 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ZNF23 zinc finger protein 23 (KOX 16)".

[6] Zhou, L., zhu, C., Luo, K., Li, Y., Pi, H., Yuan, W., Wang, Y., Huang, C., Liu, M., Wu, X. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Biochem. Biophys. Res. Commun. 295: 862-868, 2002. PubMed: 12127974

[7] Cannizzaro, L. A., Aronson, M. M., Thiesen, H. J. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Hum. Genet. 91: 383-385, 1993. PubMed: 8500793

[8] Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. PubMed: 8262519

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