ABI3

ABI3
Identifikatori
Aliasi	ABI3
Vanjski ID-jevi	OMIM: 606363 MGI: 1913860 HomoloGene: 9505 GeneCards: ABI3
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	49,223,225 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	95,733,302 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina; • SH3 domain binding;
Ćelijska komponenta	• citoplazma; • intracellular anatomical structure; • membrana; • lamellipodium;
Biološki proces	• peptidyl-tyrosine phosphorylation; • regulation of cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	51225
	66610
	ENSG00000108798
	ENSMUSG00000018381
	Q9P2A4
	Q8BYZ1
	NM_001135186; NM_016428
	NM_001163464; NM_025659
	NP_001128658; NP_057512
	NP_001156936; NP_079935
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 3 genske oporodice (ABI3), znan i kao nova molekula sa SH3 (Nesh), jest protein koji je kod ljudi kodiran genom ABI3.^[5]^[6]^[7]

Dužina polipeptidnog kanca mu je 366 aminokiselina, a molekulska težina je 39.035.^[8]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAELQQLQEF	EIPTGREALR	GNHSALLRVA	DYCEDNYVQA	TDKRKALEET
MAFTTQALAS	VAYQVGNLAG	HTLRMLDLQG	AALRQVEARV	STLGQMVNMH
MEKVARREIG	TLATVQRLPP	GQKVIAPENL	PPLTPYCRRP	LNFGCLDDIG
HGIKDLSTQL	SRTGTLSRKS	IKAPATPASA	TLGRPPRIPE	PVHLPVVPDG
RLSAASSAFS	LASAGSAEGV	GGAPTPKGQA	APPAPPLPSS	LDPPPPPAAV
EVFQRPPTLE	ELSPPPPDEE	LPLPLDLPPP	PPLDGDELGL	PPPPPGFGPD
EPSWVPASYL	EKVVTLYPYT	SQKDNELSFS	EGTVICVTRR	YSDGWCEGVS
SEGTGFFPGN	YVEPSC

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana porodice pretvara signal proteinskog adaptera. Članovi ove porodice kodiraju proteine koji sadrže homeoboksni homologni domen, prolinom bogate regije i domen Src-homologije 3 (SH3). Kodirani protein inhibira ektopiijske metafaze tumorskih ćelija kao i imigraciju ćelija. To se može postići interakcijom sa p21-aktiviranim kinazama^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018381 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
^ ^a ^b "Entrez Gene: ABI3 ABI gene family, member 3".
^ "UniProt, Q9P2A4". Pristupljeno September 12; 2017. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

Vanjski linkovi[uredi | uredi izvor]

Šablon:UCSC genE info

Dopunska literatura[uredi | uredi izvor]

Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
Miyazaki K, Matsuda S, Ichigotani Y, et al. (2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim. Biophys. Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Matsuda S, Iriyama C, Yokozaki S, et al. (2001). "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3". J. Hum. Genet. 46 (8): 483–6. doi:10.1007/s100380170049. PMID 11501947.
Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018381 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978530-5] Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.

[pmid11956071-6] Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.

[entrez-7] "Entrez Gene: ABI3 ABI gene family, member 3".

[UniProt-8] "UniProt, Q9P2A4". Pristupljeno September 12; 2017. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

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