ABLIM3

ABLIM3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1UJS, 2DJ7
Identifikatori
Aliasi	ABLIM3
Vanjski ID-jevi	OMIM: 611305 MGI: 2442582 HomoloGene: 69175 GeneCards: ABLIM3
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	149,260,542 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	62,044,895 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • actin binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • stress fiber; • lamellipodium;
Biološki proces	• cytoskeleton organization; • actin cytoskeleton organization; • transcription, DNA-templated; • lamellipodium assembly; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein targeting to mitochondrion; • cilium assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	22885
	319713
	ENSG00000173210
	ENSMUSG00000032735
	O94929
	Q69ZX8
NM_001301015; NM_001301018; NM_001301027; NM_001301028; NM_014945;
	NM_001345858; NM_001345859; NM_001345860; NM_001345861; NM_001370417; NM_001370418
	NM_001164491; NM_198649; NM_001360868
NP_001287944; NP_001287947; NP_001287957; NP_001332787; NP_001332788;
	NP_001332789; NP_001332790; NP_055760; NP_001357346; NP_001357347
	NP_001157963; NP_941051; NP_001347797
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Aktin-vezujući LIM protein 3 jest protein koji je kod ljudi kodiran genom ABLIM3.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 683 aminokiseline, а molekulska težina 77.802 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNTSIPYQQN	PYNPRGSSNV	IQCYRCGDTC	KGEVVRVHNN	HFHIRCFTCQ
VCGCGLAQSG	FFFKNQEYIC	TQDYQQLYGT	RCDSCRDFIT	GEVISALGRT
YHPKCFVCSL	CRKPFPIGDK	VTFSGKECVC	QTCSQSMASS	KPIKIRGPSH
CAGCKEEIKH	GQSLLALDKQ	WHVSCFKCQT	CSVILTGEYI	SKDGVPYCES
DYHAQFGIKC	ETCDRYISGR	VLEAGGKHYH	PTCARCVRCH	QMFTEGEEMY
LTGSEVWHPI	CKQAARAEKK	LKHRRTSETS	ISPPGSSIGS	PNRVICAKVD
NEILNYKDLA	ALPKVKSIYE	VQRPDLISYE	PHSRYMSDEM	LERCGYGESL
GTLSPYSQDI	YENLDLRQRR	ASSPGYIDSP	TYSRQGMSPT	FSRSPHHYYR
SGPESGRSSP	YHSQLDVRSS	TPTSYQAPKH	FHIPAGDSNI	YRKPPIYKRH
GDLSTATKSK	TSEDISQTSK	YSPIYSPDPY	YASESEYWTY	HGSPKVPRAR
RFSSGGEEDD	FDRSMHKLQS	GIGRLILKEE	MKARSSSYAD	PWTPPRSSTS
SREALHTAGY	EMSLNGSPRS	HYLADSDPLI	SKSASLPAYR	RNGLHRTPSA
DLFHYDSMNA	VNWGMREYKI	YPYELLLVTT	RGRNRLPKDV	DRTRLERHLS
QEEFYQVFGM	TISEFDRLAL	WKRNELKKQA	RLF

Funkcija[uredi | uredi izvor]

LIM domen je dvostruka cinkoprstna struktura koja promovira interakcije protein-protein. Proteini domena LIM, poput ABLIM3, imaju ulogu u embrionskom razvoju, određivanju ćelijske loze i raku.^[7] Važan paralog ovog gena je LIMS1.

Klinički značaj[uredi | uredi izvor]

Bolesti povezane s ABLIM3 uključuju hepatoblastom, a među njegovim povezanim super-putevima su navođenje akson a i DCC posredovanu atraktivnu signalizaciu.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173210 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032735 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".
^ "UniProt, O94929" (jezik: engleski). Pristupljeno 12. 10. 2021.
^ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (Aug 2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005.
Zheng B, Wen JK, Han M, Zhou AR (Sep 2004). "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690 (1): 1–10. doi:10.1016/j.bbadis.2004.04.009. PMID 15337165.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N (Mar 2007). "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry. 282 (11): 8393–8403. doi:10.1074/jbc.M607549200. PMID 17194709.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma ABLIM3 i stranica sa detaljima o genu ABLIM3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173210 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032735 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".

[UniProt-6] "UniProt, O94929" (jezik: engleski). Pristupljeno 12. 10. 2021.

[7] Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.

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