AZI1

AZI1
Identifikatori
Aliasi	CEP131
Vanjski ID-jevi	OMIM: 613479 MGI: 107440 HomoloGene: 7638 GeneCards: CEP131
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	81,222,999 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	120,086,827 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• citoplazma; • citosol; • centrosom; • projekcija ćelije; • intracellular membrane-bounded organelle; • microtubule cytoskeleton; • centriolar satellite; • centar organizacije mikrotubula; • Akrozom; • intercellular bridge; • citoskelet; • GO:0016023 citoplazmatska vezikula; • ciliary transition zone; • ciliary basal body; • Treplja;
Biološki proces	• positive regulation of intracellular protein transport; • Ćelijska diferencijacija; • regulation of centrosome duplication; • multicellular organism development; • intraciliary transport involved in cilium assembly; • cell projection organization; • G2/M transition of mitotic cell cycle; • Spermatogeneza; • positive regulation of cell population proliferation; • protein localization to centrosome; • ćelijski ciklus; • ciliary basal body-plasma membrane docking; • regulation of G2/M transition of mitotic cell cycle; • cilium assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	22994
	12009
	ENSG00000141577
	ENSMUSG00000039781
	Q9UPN4
	Q62036
	NM_001009811; NM_014984; NM_001319228; NM_001319229
	NM_009734
	NP_001009811; NP_001306157; NP_001306158; NP_055799
	NP_033864; NP_001390635; NP_001390663
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

5-azacitidin-inducirani protein 1 jest protein koji je kod ljudi kodiran genom AZI1.^[5]^[6]^[7]^[8]

Dužina polipeptidnog lanca je 1.083 aminokiseline, sa molekulskom težinom od 122.149.^[9]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MKGTRAIGSV	PERSPAGVDL	SLTGLPPPVS	RRPGSAATTK	PIVRSVSVVT
GSEQKRKVLE	ATGPGGSQAI	NNLRRSNSTT	QVSQPRSGSP	RPTEPTDFLM
LFEGSPSGKK	RPASLSTAPS	EKGATWNVLD	DQPRGFTLPS	NARSSSALDS
PAGPRRKECT	VALAPNFTAN	NRSNKGAVGN	CVTTMVHNRY	TPSERAPPLK
SSNQTAPSLN	NIIKAATCEG	SESSGFGKLP	KNVSSATHSA	RNNTGGSTGL
PRRKEVTEEE	AERFIHQVNQ	ATVTIQRWYR	HQVQRRGAGA	ARLEHLLQAK
REEQRQRSGE	GTLLDLHQQK	EAARRKAREE	KARQARRAAI	QELQQKRALR
AQKASTAERG	PPENPRETRV	PGMRQPAQEL	SPTPGGTAHQ	ALKANNTGGG
LPAAGPGDRC	LPTSDSSPEP	QQPPEDRTQD	VLAQDAAGDN	LEMMAPSRGS
AKSRGPLEEL	LHTLQLLEKE	PDVLPRPRTH	HRGRYAWASE	VTTEDDASSL
TADNLEKFGK	LSAFPEPPED	GTLLSEAKLQ	SIMSFLDEME	KSGQDQLDSQ
QEGWVPEAGP	GPLELGSEVS	TSVMRLKLEV	EEKKQAMLLL	QRALAQQRDL
TARRVKETEK	ALSRQLQRQR	EHYEATIQRH	LAFIDQLIED	KKVLSEKCEA
VVAELKQEDQ	RCTERVAQAQ	AQHELEIKKL	KELMSATEKA	RREKWISEKT
KKIKEVTVRG	LEPEIQKLIA	RHKQEVRRLK	SLHEAELLQS	DERASQRCLR
QAEELREQLE	REKEALGQQE	RERARQRFQQ	HLEQEQWALQ	QQRQRLYSEV
AEERERLGQQ	AARQRAELEE	LRQQLEESSS	ALTRALRAEF	EKGREEQERR
HQMELNTLKQ	QLELERQAWE	AGRTRKEEAW	LLNREQELRE	EIRKGRDKEI
ELVIHRLEAD	MALAKEESEK	AAESRIKRLR	DKYEAELSEL	EQSERKLQER
CSELKGQLGE	AEGENLRLQG	LVRQKERALE	DAQAVNEQLS	SERSNLAQVI
RQEFEDRLAA	SEEETRQAKA	ELATLQARQQ	LELEEVHRRV	KTALARKEEA
VSSLRTQHEA	AVKRADHLEE	LLEQHRRPTP	STK

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141577 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039781 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
^ Aoto H, Miyake Y, Nakamura M, Tajima S (1997). "Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids". Genomics. 40 (1): 138–41. doi:10.1006/geno.1996.4546. PMID 9070930.
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
^ "Entrez Gene: AZI1 5-azacytidine induced 1".
^ "UniProt, Q9UPN4". Pristupljeno 12. 9. 2017.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CEP131 i stranica sa detaljima o genu CEP131 u UCSC Genome Browseru.

Dopunska literatura[uredi | uredi izvor]

Aoto H, Tsuchida J, Nishina Y, Nishimune Y, Asano A, Tajima S (1995). "Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids". Eur. J. Biochem. 234 (1): 8–15. doi:10.1111/j.1432-1033.1995.008_c.x. PMID 8529672.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141577 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039781 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10470851-5] Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.

[pmid9070930-6] Aoto H, Miyake Y, Nakamura M, Tajima S (1997). "Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids". Genomics. 40 (1): 138–41. doi:10.1006/geno.1996.4546. PMID 9070930.

[pmid14654843-7] Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.

[entrez-8] "Entrez Gene: AZI1 5-azacytidine induced 1".

[UniProt-9] "UniProt, Q9UPN4". Pristupljeno 12. 9. 2017.

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