CAMTA1

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CAMTA1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2CXK

Identifikatori
AliasiCAMTA1
Vanjski ID-jeviOMIM: 611501 MGI: 2140230 HomoloGene: 18942 GeneCards: CAMTA1
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[1]
Hromosom 4 (miš)
Genomska lokacija za CAMTA1
Genomska lokacija za CAMTA1
Bend4|4 E2Početak150,917,322 bp[1]
Kraj151,861,876 bp[1]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• sequence-specific DNA binding
• vezivanje sa DNK
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta• jedro
• Jedarce
• citoplazma
• citosol
Biološki proces• GO:0009373 regulation of transcription, DNA-templated
• neuromuscular process controlling balance
• transcription, DNA-templated
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II
• positive regulation of protein dephosphorylation
• positive regulation of calcineurin-NFAT signaling cascade
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

23261

100072

Ensembl

ENSG00000171735

ENSMUSG00000014592

UniProt

Q9Y6Y1

A2A891

RefSeq (mRNK)

NM_001195563
NM_001242701
NM_015215

NM_001081557
NM_001166021
NM_001195565

RefSeq (bjelančevina)
NP_001182492
NP_001229630
NP_056030
NP_001336537
NP_001336538

NP_001336539
NP_001336541
NP_001336542
NP_001336543
NP_001336544
NP_001336545
NP_001336546
NP_001336547
NP_001336548
NP_001336549
NP_001336550
NP_001336551
NP_001336552
NP_001336553
NP_001336554
NP_001336555
NP_001336556

NP_001075026
NP_001182494

Lokacija (UCSC)n/aChr 4: 150.92 – 151.86 Mb
PubMed pretraga[2][3]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Kalmodulin-vezujući transkripcijski aktivator 1 jest protein koji je kod ljudi kodiran genom CAMTA1 sa hromosoma 1.[4][5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.673 aminokiselina, a molekulska težina 183.672 Da.[6]

1020304050
MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVK
IFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKT
RPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYG
CYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSIN
TDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDS
HQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSH
SEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVE
VPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVF
MSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSS
ESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGG
GGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSS
SAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFS
QTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTE
ASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEG
SEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQP
SLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDS
TALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAE
VVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASN
NYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVF
EYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHK
QASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRAC
WAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELE
VDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGI
ARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSE
AISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNP
EYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSREL
SPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAP
SQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTL
AEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCL
PSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLS
ASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVA
AAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLI
QKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRC
RHSPLVDHRLYKRSERIEKGQGT

Reference[uredi | uredi izvor]

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014592 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H (Jun 2002). "A novel family of calmodulin-binding transcription activators in multicellular organisms". Journal of Biological Chemistry. 277 (24): 21851–61. doi:10.1074/jbc.M200268200. PMID 11925432. S2CID 9090244.
  5. ^ "Entrez Gene: CAMTA1 calmodulin binding transcription activator 1".
  6. ^ "UniProt, Q9Y6Y1" (jezik: engleski). Pristupljeno 22. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

  • Katoh M, Katoh M (2004). "Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23". International Journal of Oncology. 23 (4): 1219–24. doi:10.3892/ijo.23.4.1219. PMID 12964007.
  • Nakatani K, Nishioka J, Itakura T, et al. (2004). "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells". Int. J. Oncol. 24 (6): 1407–12. doi:10.3892/ijo.24.6.1407 (neaktivno 31. 10. 2021). PMID 15138581.CS1 održavanje: DOI nije aktivan od 2021 (link)
  • Barbashina V, Salazar P, Holland EC, et al. (2005). "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clinical Cancer Research. 11 (3): 1119–28. PMID 15709179.
  • Henrich KO, Claas A, Praml C, et al. (2007). "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma". European Journal of Cancer. 43 (3): 607–16. doi:10.1016/j.ejca.2006.09.023. PMID 17222547.
  • Huentelman MJ, Papassotiropoulos A, Craig DW, et al. (2007). "Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance" (PDF). Human Molecular Genetics. 16 (12): 1469–77. doi:10.1093/hmg/ddm097. PMID 17470457.

Vanjski linkovi[uredi | uredi izvor]

Preuzeto iz "https://bs.wikipedia.org/w/index.php?title=CAMTA1&oldid=3375594"