CCL4L1

CCL4L1
Identifikatori
Aliasi	CCL4L2
Vanjski ID-jevi	OMIM: 610757 GeneCards: CCL4L2
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	36,212,878 bp
Ontologija gena
Molekularna funkcija	• chemokine activity; • cytokine activity; • GO:0001948, GO:0016582 vezivanje za proteine; • CCR chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• lymphocyte chemotaxis; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • G protein-coupled receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • Hemotaksija; • inflammatory response; • cellular response to interleukin-1; • monocyte chemotaxis; • neutrophil chemotaxis; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • regulation of signaling receptor activity; • eosinophil chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	9560
	n/a
	ENSG00000276070; ENSG00000275313; ENSG00000276125; ENSG00000282604
	n/a
	Q8NHW4
	n/a
NM_001001435; NM_001291468; NM_001291469; NM_001291470; NM_001291471;
	NM_001291472; NM_001291473; NM_001291474; NM_001291475
	n/a
	NP_996890
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

C-C motiv koji liči na hemokin 4 je protein koji je kod ljudi kodiran genom CCL4L1.^[3]^[4]^[5]^[6]

CCL4L2 je telomerna kopija gena CCL4L1. Sekvenciranjem BAC klona smještenog u segmentnoj duplikaciji na hromoomu 17, sekvenca q12, identificirane su dvije cjelovite kopije gena CCL3L1 i CCL4L1.

Dužina polipeptidnog lanca je 92 aminokiseline, a molekulska težina 10.166 Da.^[7]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MKLCVTVLSL		LVLVAAFCSL		ALSAPMGSDP		PTACCFSYTA		RKLPRNFVVD
YYETSSLCSQ		PAVVFQTKRG		KQVCADPSES		WVQEYVYDLE		LN

Funkcija[uredi | uredi izvor]

Ovaj gen je jedan od nekoliko citokinskih gena na q-kraku hromosoma 17. Citokini su porodica izlučenih proteina koji su uključeni u imunoregulatorne i upalne procese. Ovaj protein sličan je CCL4 koji inhibira ulazak HIV-a, vezujući se za ćelijski receptor CCR5. Broj kopija ovog gena razlikuje se među osobama; većina ima 1-5 kopija u diploidnom genomu, iako rijetke osobe uopće ne sadrže ovaj gen. Ljudski genomski referentni sklop sadrži dvije kopije ovog gena. Ovaj transript predstavlja centromerne gene.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000275313, ENSG00000276125, ENSG00000282604 GRCh38: Ensembl release 89: ENSG00000276070, ENSG00000275313, ENSG00000276125, ENSG00000282604 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Coillie EV, Opdenakker G, Gunge N, Sakaki Y, Iio M, Miura R (Feb 1997). "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2". Genomics. 34 (2): 236–40. doi:10.1006/geno.1996.0274. PMID 8661057.
^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (Jul 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
^ Modi WS (Mar 2004). "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12". Genomics. 83 (4): 735–8. doi:10.1016/j.ygeno.2003.09.019. PMID 15028295.
^ ^a ^b "Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1". Pristupljeno 8. 2. 2013.
^ "UniProt, Q8NHW4". Pristupljeno 21. 6. 2021.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CCL4L2 i stranica sa detaljima o genu CCL4L2 u UCSC Genome Browseru.

Dopunska literatura[uredi | uredi izvor]

Menten P, Wuyts A, Van Damme J (2003). "Macrophage inflammatory protein-1". Cytokine Growth Factor Rev. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
Napolitano M, Modi WS, Cevario SJ, et al. (1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization". J. Biol. Chem. 266 (26): 17531–6. PMID 1894635.
Baixeras E, Roman-Roman S, Jitsukawa S, et al. (1991). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Mol. Immunol. 27 (11): 1091–102. doi:10.1016/0161-5890(90)90097-J. PMID 2247088.
Lipes MA, Napolitano M, Jeang KT, et al. (1989). "Identification, cloning, and characterization of an immune activation gene". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9704–8. doi:10.1073/pnas.85.24.9704. PMC 282843. PMID 2462251.
Brown KD, Zurawski SM, Mosmann TR, Zurawski G (1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes". J. Immunol. 142 (2): 679–87. PMID 2521353.
Zipfel PF, Balke J, Irving SG, et al. (1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors". J. Immunol. 142 (5): 1582–90. PMID 2521882.
Chang HC, Reinherz EL (1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes". Eur. J. Immunol. 19 (6): 1045–51. doi:10.1002/eji.1830190614. PMID 2568930.
Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes". J. Immunol. 143 (9): 2907–16. PMID 2809212.
Lodi PJ, Garrett DS, Kuszewski J, et al. (1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762–7. doi:10.1126/science.8134838. PMID 8134838.
Cocchi F, DeVico AL, Garzino-Demo A, et al. (1996). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.
Bernardini G, Hedrick J, Sozzani S, et al. (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068.
Garlisi CG, Xiao H, Tian F, et al. (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
Modi WS, Bergeron J, Sanford M (2001). "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1". Immunogenetics. 53 (7): 543–9. doi:10.1007/s002510100366. PMID 11685466. S2CID 26940744.
Guan E, Wang J, Roderiquez G, Norcross MA (2002). "Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity". J. Biol. Chem. 277 (35): 32348–52. doi:10.1074/jbc.M203077200. PMID 12070155.
Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". Eur. J. Immunol. 32 (10): 3016–26. doi:10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D. PMID 12355456.
Lu J, Honczarenko M, Sloan SR (2004). "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes". Immunogenetics. 55 (10): 706–11. doi:10.1007/s00251-003-0636-z. PMID 14673550. S2CID 22941034.

[refGRCh38Ensembl-1] ENSG00000275313, ENSG00000276125, ENSG00000282604 GRCh38: Ensembl release 89: ENSG00000276070, ENSG00000275313, ENSG00000276125, ENSG00000282604 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661057-3] Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Coillie EV, Opdenakker G, Gunge N, Sakaki Y, Iio M, Miura R (Feb 1997). "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2". Genomics. 34 (2): 236–40. doi:10.1006/geno.1996.0274. PMID 8661057.

[pmid1972563-4] Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (Jul 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.

[pmid15028295-5] Modi WS (Mar 2004). "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12". Genomics. 83 (4): 735–8. doi:10.1016/j.ygeno.2003.09.019. PMID 15028295.

[entrez-6] "Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1". Pristupljeno 8. 2. 2013.

[UniProt-7] "UniProt, Q8NHW4". Pristupljeno 21. 6. 2021.

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