DHX15

DHX15
Identifikatori
Aliasi	DHX15
Vanjski ID-jevi	OMIM: 603403 MGI: 1099786 HomoloGene: 1040 GeneCards: DHX15
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	24,584,554 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	52,347,856 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• RNA helicase activity; • nucleotide binding; • double-stranded RNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • GO:0008026 helicase activity; • hydrolase activity; • nucleic acid binding; • vezivanje sa RNK; • GO:0034459 3'-5' RNA helicase activity;
Ćelijska komponenta	• U12-type spliceosomal complex; • Jedarce; • U2-type post-mRNA release spliceosomal complex; • citoplazma; • jedro; • nukleoplazma; • nuclear speck;
Biološki proces	• mRNA processing; • response to alkaloid; • response to toxic substance; • Prerada RNK; • mRNA splicing, via spliceosome;
	Izvori:Amigo / QuickGO
Ortolozi
	1665
	13204
	ENSG00000109606
	ENSMUSG00000029169
	O43143
	O35286
	NM_001358
	NM_001042620; NM_007839
	NP_001349
	NP_001036085; NP_031865
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pretpostavljeni faktor pre-iRNK-preradne ATP-ovisne RNK-helikaze DHX15 jest enzim koji je kod ljudi kodiran genom DHX15 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 795 aminokiselina, а molekulska težina 90.933 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSKRHRLDLG	EDYPSGKKRA	GTDGKDRDRD	RDREDRSKDR	DRERDRGDRE
REREKEKEKE	LRASTNAMLI	SAGLPPLKAS	HSAHSTHSAH	STHSTHSAHS
THAGHAGHTS	LPQCINPFTN	LPHTPRYYDI	LKKRLQLPVW	EYKDRFTDIL
VRHQSFVLVG	ETGSGKTTQI	PQWCVEYMRS	LPGPKRGVAC	TQPRRVAAMS
VAQRVADEMD	VMLGQEVGYS	IRFEDCSSAK	TILKYMTDGM	LLREAMNDPL
LERYGVIILD	EAHERTLATD	ILMGVLKEVV	RQRSDLKVIV	MSATLDAGKF
QIYFDNCPLL	TIPGRTHPVE	IFYTPEPERD	YLEAAIRTVI	QIHMCEEEEG
DLLLFLTGQE	EIDEACKRIK	REVDDLGPEV	GDIKIIPLYS	TLPPQQQQRI
FEPPPPKKQN	GAIGRKVVVS	TNIAETSLTI	DGVVFVIDPG	FAKQKVYNPR
IRVESLLVTA	ISKASAQQRA	GRAGRTRPGK	CFRLYTEKAY	KTEMQDNTYP
EILRSNLGSV	VLQLKKLGID	DLVHFDFMDP	PAPETLMRAL	ELLNYLAALN
DDGDLTELGS	MMAEFPLDPQ	LAKMVIASCD	YNCSNEVLSI	TAMLSVPQCF
VRPTEAKKAA	DEAKMRFAHI	DGDHLTLLNV	YHAFKQNHES	VQWCYDNFIN
YRSLMSADNV	RQQLSRIMDR	FNLPRRSTDF	TSRDYYINIR	KALVTGYFMQ
VAHLERTGHY	LTVKDNQVVQ	LHPSTVLDHK	PEWVLYNEFV	LTTKNYIRTC
TDIKPEWLVK	IAPQYYDMSN	FPQCEAKRQL	DRIIAKLQSK	EYSQY

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je navodna ATP-zavisna RNK-helikaza uključena u preradu iRNK.^[6] Može imati tumor-supresorsku aktivnost.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
^ ^a ^b "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".
^ "UniProt, O43143" (jezik: engleski). Pristupljeno 25. 10. 2021.
^ Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi:10.1038/bjc.2017.273. PMC 5672939. PMID 28829764.

Dopunska literatura[uredi | uredi izvor]

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349. PMID 12458796.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. doi:10.1128/MCB.14.11.7611. PMC 359297. PMID 7935475.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388478-5] Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.

[entrez-6] "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

[UniProt-7] "UniProt, O43143" (jezik: engleski). Pristupljeno 25. 10. 2021.

[sitobmj2017-8] Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi:10.1038/bjc.2017.273. PMC 5672939. PMID 28829764.

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