DKK2

DKK2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2JTK
Identifikatori
Aliasi	DKK2
Vanjski ID-jevi	OMIM: 605415 MGI: 1890663 HomoloGene: 8681 GeneCards: DKK2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	107,283,806 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	131,886,065 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• co-receptor binding; • receptor antagonist activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• positive regulation of canonical Wnt signaling pathway; • multicellular organism development; • negative regulation of Wnt signaling pathway; • Wnt-signalni put; • negative regulation of canonical Wnt signaling pathway; • extracellular negative regulation of signal transduction; • negative regulation of signaling receptor activity;
	Izvori:Amigo / QuickGO
Ortolozi
	27123
	56811
	ENSG00000155011
	ENSMUSG00000028031
	Q9UBU2
	Q9QYZ8
	NM_014421
	NM_020265
	NP_055236
	NP_064661
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Debeloglavom proteinu srodni protein 2 jest protein koji je kod ljudi kodiran genom DKK2 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 259 aminokiselina, а molekulska težina 28.447 Da.^[7].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAALMRSKDS	SCCLLLLAAV	LMVESSQIGS	SRAKLNSIKS	SLGGETPGQA
ANRSAGMYQG	LAFGGSKKGK	NLGQAYPCSS	DKECEVGRYC	HSPHQGSSAC
MVCRRKKKRC	HRDGMCCPST	RCNNGICIPV	TESILTPHIP	ALDGTRHRDR
NHGHYSNHDL	GWQNLGRPHT	KMSHIKGHEG	DPCLRSSDCI	EGFCCARHFW
TKICKPVLHQ	GEVCTKQRKK	GSHGLEIFQR	CDCAKGLSCK	VWKDATYSSK
ARLHVCQKI

Funkcija[uredi | uredi izvor]

Ovaj gen kodira protein koji je član porodice debeloglavih proteina. Izlučeni protein sadrži dvije regije bogate cisteinom i uključen je u razvoj embrija, preko svoje interakcije sa Wnt signalnog put.

Može djelovati ili kao agonist ili kao antagonist Wnt/beta-katenin signalizacije, ovisno o ćelijskom kontekstu i prisutnosti kofaktora flint 2. Aktivnost ovog proteina je također modulirana vezivanjem za Wnt koreceptor LDL-receptorski povezani protein 6 (LRP6).^[6]

Također pogledajte[uredi | uredi izvor]

Dlakavi dlanovi i tabani^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155011 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028031 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (oktobar 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
^ ^a ^b "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".
^ "UniProt, Q9UBU2" (jezik: engleski). Pristupljeno 25. 10. 2021.
^ Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, et al. (decembar 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017. PMC 6345517. PMID 30509557.

Dopunska literatura[uredi | uredi izvor]

Wu W, Glinka A, Delius H, Niehrs C (2001). "Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling". Current Biology. 10 (24): 1611–4. doi:10.1016/S0960-9822(00)00868-X. PMID 11137016. S2CID 6397269.
Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (maj 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. S2CID 4323027.
Li L, Mao J, Sun L, Liu W, Wu D (februar 2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled". The Journal of Biological Chemistry. 277 (8): 5977–81. doi:10.1074/jbc.M111131200. PMID 11742004.
Brott BK, Sokol SY (septembar 2002). "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins". Molecular and Cellular Biology. 22 (17): 6100–10. doi:10.1128/MCB.22.17.6100-6110.2002. PMC 133995. PMID 12167704.
Mao B, Niehrs C (januar 2003). "Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling". Gene. 302 (1–2): 179–83. doi:10.1016/S0378-1119(02)01106-X. PMID 12527209.
Kuphal S, Lodermeyer S, Bataille F, Schuierer M, Hoang BH, Bosserhoff AK (august 2006). "Expression of Dickkopf genes is strongly reduced in malignant melanoma". Oncogene. 25 (36): 5027–36. doi:10.1038/sj.onc.1209508. PMID 16568085.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155011 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028031 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10570958-5] Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (oktobar 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.

[entrez-6] "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".

[UniProt-7] "UniProt, Q9UBU2" (jezik: engleski). Pristupljeno 25. 10. 2021.

[8] Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, et al. (decembar 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017. PMC 6345517. PMID 30509557.

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