English: Structure of the PAX3 gene, mRNA and protein. The exons in the DNA and mRNA diagrams are numbered, and a horizontal arrow in the DNA diagram shows the promoter and direction of transcription. The start and stop codons are shown in the mRNA diagram by the vertical arrows. Conserved regions are indicated by open boxes in the protein diagram, and functional domains are indicated as thick horizontal lines above the protein diagram. Representative sizes are shown by the thin horizontal line segments in the DNA, mRNA and protein diagrams. Abbreviations: PB, paired box domain; HD, homeodomain; PST, proline-, serine- and threonine-rich region; DBD, DNA binding domain; TAD, transcription activation domain.
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