EIF5AP1

EIF5AP1
Identifikatori
Aliasi	EIF5AL1
Vanjski ID-jevi	HomoloGene: 100947 GeneCards: EIF5AL1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	79,516,440 bp
Ontologija gena
Molekularna funkcija	• translation elongation factor activity; • vezivanje sa RNK; • ribosome binding;
Ćelijska komponenta	• Jedrova pora; • endoplasmic reticulum membrane; • jedro; • membrana; • citoplazma; • Endoplazmatski retikulum;
Biološki proces	• protein transport; • translational frameshifting; • positive regulation of translational elongation; • translational elongation; • mRNA transport; • Biosinteza bjelančevina; • positive regulation of translational termination;
	Izvori:Amigo / QuickGO
Ortolozi
	143244
	n/a
	ENSG00000253626
	n/a
	Q6IS14
	n/a
	NM_001099692
	n/a
	NP_001093162
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Pseudogen 1 eukariotskog faktora 5A translacijske inicijacije, znan i kao EIF5AP1, je ljudski gen.^[3]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 154 aminokiseline, а molekulska težina 16.773^[4].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MADDLDFETG	DAGASATFPM	QCSALRKNGF	VVLKGWPCKI	VEMSASKTGK
HGHAKVHLVG	IDIFTGKKYE	DICPSTHNMD	VPNIKRNDFQ	LIGIQDGYLS
LLQDSGEVPE	DLRLPEGDLG	KEIEQKYDCG	EEILITVLSA	MTEEAAVAIK
AMAK

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253626 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EIF5AP1 eukaryotic translation initiation factor 5A pseudogene 1".
^ "UniProt, Q6IS14". Pristupljeno 1. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–618. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.
Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells". FEBS J. 273 (6): 1102–1114. doi:10.1111/j.1742-4658.2006.05135.x. PMC 4406228. PMID 16519677.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Facchiano AM, Stiuso P, Chiusano ML, et al. (2002). "Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A)". Protein Eng. 14 (11): 881–890. doi:10.1093/protein/14.11.881. PMID 11742107.
Lipowsky G, Bischoff FR, Schwarzmaier P, et al. (2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–4371. doi:10.1093/emboj/19.16.4362. PMC 302028. PMID 10944119.
Ruhl M, Himmelspach M, Bahr GM, et al. (1994). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation". J. Cell Biol. 123 (6 Pt 1): 1309–1320. doi:10.1083/jcb.123.6.1309. PMC 2290910. PMID 8253832.
Steinkasserer A, Jones T, Sheer D, et al. (1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.
Koettnitz K, Wöhl T, Kappel B, et al. (1995). "Identification of a new member of the human eIF-5A gene family". Gene. 159 (2): 283–284. doi:10.1016/0378-1119(95)00136-T. PMID 7622067.
Koettnitz K, Kappel B, Baumruker T, et al. (1994). "The genomic structure encoding human initiation factor eIF-5A". Gene. 144 (2): 249–252. doi:10.1016/0378-1119(94)90385-9. PMID 7545941.
Park MH, Liu TY, Neece SH, Swiggard WJ (1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue". J. Biol. Chem. 261 (31): 14515–9. PMID 3095320.
Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein". J. Biol. Chem. 264 (3): 1578–83. PMID 2492279.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000253626 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: EIF5AP1 eukaryotic translation initiation factor 5A pseudogene 1".

[UniProt-4] "UniProt, Q6IS14". Pristupljeno 1. 9. 2021.

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