ENAH

ENAH
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2HO2, 2IYB, 2XQN, 4MY6
Identifikatori
Aliasi	ENAH
Vanjski ID-jevi	OMIM: 609061 MGI: 108360 HomoloGene: 134005 GeneCards: ENAH
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	225,653,142 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	181,847,555 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• SH3 domain binding; • WW domain binding; • actin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • profilin binding;
Ćelijska komponenta	• Filopodija; • međućelijske veze; • ćelijska membrana; • projekcija ćelije; • sinapsa; • citoskelet; • focal adhesion; • lamellipodium; • citoplazma; • citosol;
Biološki proces	• axon guidance; • actin polymerization or depolymerization; • actin polymerization-dependent cell motility;
	Izvori:Amigo / QuickGO
Ortolozi
	55740
	13800
	ENSG00000154380
	ENSMUSG00000022995
	Q8N8S7
	Q03173
	NM_001008493; NM_018212
	NM_001083120; NM_001083121; NM_008680; NM_010135
	NP_001008493; NP_060682; NP_001364410; NP_001364411; NP_001364412
	NP_001076589; NP_001076590; NP_032706; NP_034265
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Omogućeni proteinski homolog jest protein koji je kod ljudi kodiran genom ENAH sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 591 aminokiselina, a molekulska težina 66.510 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEQSICQAR	AAVMVYDDAN	KKWVPAGGST	GFSRVHIYHH	TGNNTFRVVG
RKIQDHQVVI	NCAIPKGLKY	NQATQTFHQW	RDARQVYGLN	FGSKEDANVF
ASAMMHALEV	LNSQETGPTL	PRQNSQLPAQ	VQNGPSQEEL	EIQRRQLQEQ
QRQKELERER	LERERMERER	LERERLERER	LERERLEQEQ	LERERQERER
QERLERQERL	ERQERLERQE	RLDRERQERQ	ERERLERLER	ERQERERQEQ
LEREQLEWER	ERRISSAAAP	ASVETPLNSV	LGDSSASEPG	LQAASQPAET
PSQQGIVLGP	LAPPPPPPLP	PGPAQASVAL	PPPPGPPPPP	PLPSTGPPPP
PPPPPLPNQV	PPPPPPPPAP	PLPASGFFLA	SMSEDNRPLT	GLAAAIAGAK
LRKVSRMEDT	SFPSGGNAIG	VNSASSKTDT	GRGNGPLPLG	GSGLMEEMSA
LLARRRRIAE	KGSTIETEQK	EDKGEDSEPV	TSKASSTSTP	EPTRKPWERT
NTMNGSKSPV	ISRRDSPRKN	QIVFDNRSYD	SLHRPKSTPL	SQPSANGVQT
EGLDYDRLKQ	DILDEMRKEL	TKLKEELIDA	IRQELSKSNT	A

Interakcije[uredi | uredi izvor]

Pokazano je da ENAH gen ima interakcije sa ABI1^[8] i ZYX.^[8]^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (decembar 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta. 1132 (3): 240–8. doi:10.1016/0167-4781(92)90156-t. hdl:2027.42/29785. PMID 1420303.
^ "Entrez Gene: ENAH enabled homolog (Drosophila)".
^ "UniProt, Q8N8S7" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ ^a ^b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
^ Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.

Dopunska literatura[uredi | uredi izvor]

Niebuhr K, Ebel F, Frank R, et al. (1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family". EMBO J. 16 (17): 5433–44. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
Ermekova KS, Zambrano N, Linn H, et al. (1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
Mammoto A, Sasaki T, Asakura T, et al. (1998). "Interactions of drebrin and gephyrin with profilin". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
Geese M, Schlüter K, Rothkegel M, et al. (2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed". J. Cell Sci. 113 (8): 1415–26. PMID 10725224.
Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
Drees B, Friederich E, Fradelizi J, et al. (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
Krugmann S, Jordens I, Gevaert K, et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. S2CID 11290377.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Tani K, Sato S, Sukezane T, et al. (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
Garvalov BK, Higgins TE, Sutherland JD, et al. (2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". J. Cell Biol. 161 (1): 33–9. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
Giesemann T, Schwarz G, Nawrotzki R, et al. (2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system". J. Neurosci. 23 (23): 8330–9. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687. PMID 12967995.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Stüven T, Hartmann E, Görlich D (2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
Di Modugno F, Bronzi G, Scanlan MJ, et al. (2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response". Int. J. Cancer. 109 (6): 909–18. doi:10.1002/ijc.20094. PMID 15027125.
Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1420303-5] Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (decembar 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta. 1132 (3): 240–8. doi:10.1016/0167-4781(92)90156-t. hdl:2027.42/29785. PMID 1420303.

[entrez-6] "Entrez Gene: ENAH enabled homolog (Drosophila)".

[UniProt-7] "UniProt, Q8N8S7" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid12672821-8] Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.

[pmid10801818-9] Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]