FCMR

FCMR
Identifikatori
Aliasi	FCMR
Vanjski ID-jevi	OMIM: 606015 MGI: 1916419 HomoloGene: 48347 GeneCards: FCMR
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	206,923,247 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	130,808,528 bp
Ortolozi
	9214
	69169
	ENSG00000162894
	ENSMUSG00000042474
	O60667
	A1KXC4
	NM_001142472; NM_001142473; NM_001193338; NM_005449
	NM_026976
	NP_001135945; NP_001180267; NP_005440
	NP_081252; NP_001392822
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Fc-fragment IgM receptora jest protein koji je kod ljudi kodiran genom FCMR sa hromosoma 1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 390 aminokiselina, a molekulska težina 43 146 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDFWLWPLYF	LPVSGALRIL	PEVKVEGELG	GSVTIKCPLP	EMHVRIYLCR
EMAGSGTCGT	VVSTTNFIKA	EYKGRVTLKQ	YPRKNLFLVE	VTQLTESDSG
VYACGAGMNT	DRGKTQKVTL	NVHSEYEPSW	EEQPMPETPK	WFHLPYLFQM
PAYASSSKFV	TRVTTPAQRG	KVPPVHHSSP	TTQITHRPRV	SRASSVAGDK
PRTFLPSTTA	SKISALEGLL	KPQTPSYNHH	TRLHRQRALD	YGSQSGREGQ
GFHILIPTIL	GLFLLALLGL	VVKRAVERRK	ALSRRARRLA	VRMRALESSQ
RPRGSPRPRS	QNNIYSACPR	RARGADAAGT	GEAPVPGPGA	PLPPAPLQVS
ESPWLHAPSL	KTSCEYVSLY	HQPAAMMEDS	DSDDYINVPA

Funkcija[uredi | uredi izvor]

Fc-receptori se specifično vezuju za Fc-region imunoglobulina (Igs), kako bi posredovali u jedinstvenim funkcijama svake klase Ig. FAIM3 kodira Fc-receptor za IgM (vidi MIM 147020) (Kubagawa et al., 2009. PubMed 19858324]; Shima et al., 2010 PubMed 20042454]).

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162894 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042474 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fc fragment of IgM receptor". Pristupljeno 24. 3. 2016.
^ "UniProt, O60667" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Sigruener A, Buechler C, Bared SM, Grandl M, Aslanidis C, Ugocsai P, Gehrmann M, Schmitz G (2007). "E-LDL upregulates TOSO expression and enhances the survival of human macrophages". Biochem. Biophys. Res. Commun. 359 (3): 723–8. doi:10.1016/j.bbrc.2007.05.169. PMID 17553462.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162894 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042474 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Fc fragment of IgM receptor". Pristupljeno 24. 3. 2016.

[UniProt-6] "UniProt, O60667" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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