FUBP1

FUBP1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1J4W, 2KXH, 4LIJ
Identifikatori
Aliasi	FUBP1
Vanjski ID-jevi	OMIM: 603444 MGI: 1196294 HomoloGene: 48253 GeneCards: FUBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	77,979,110 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	151,942,463 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • single-stranded DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • vezivanje sa RNK;
Ćelijska komponenta	• jedro; • nukleoplazma;
Biološki proces	• GO:1901313 positive regulation of gene expression; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	8880
	51886
	ENSG00000162613
	ENSMUSG00000028034
	Q96AE4
	Q91WJ8
	NM_001303433; NM_003902; NM_001376055; NM_001376056; NM_001376057
NM_057172; NM_001355366; NM_001355367; NM_001355368; NM_001355369;
	NM_001355370; NM_001355371; NM_001355372; NM_001355373; NM_001355374
	NP_001290362; NP_003893; NP_001362984; NP_001362985; NP_001362986
NP_476513; NP_001342295; NP_001342296; NP_001342297; NP_001342298;
	NP_001342299; NP_001342300; NP_001342301; NP_001342302; NP_001342303
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Daleki uzvodnovezujući element proteina 1 jest protein koji je kod ljudi kodiran genom FUBP1 sa hromosoma 1.^[5]^[6]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 644 aminokiseline, a molekulska težina 67.560 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MADYSTVPPP	SSGSAGGGGG	GGGGGGVNDA	FKDALQRARQ	IAAKIGGDAG
TSLNSNDYGY	GGQKRPLEDG	DQPDAKKVAP	QNDSFGTQLP	PMHQQQSRSV
MTEEYKVPDG	MVGFIIGRGG	EQISRIQQES	GCKIQIAPDS	GGLPERSCML
TGTPESVQSA	KRLLDQIVEK	GRPAPGFHHG	DGPGNAVQEI	MIPASKAGLV
IGKGGETIKQ	LQERAGVKMV	MIQDGPQNTG	ADKPLRITGD	PYKVQQAKEM
VLELIRDQGG	FREVRNEYGS	RIGGNEGIDV	PIPRFAVGIV	IGRNGEMIKK
IQNDAGVRIQ	FKPDDGTTPE	RIAQITGPPD	RCQHAAEIIT	DLLRSVQAGN
PGGPGPGGRG	RGRGQGNWNM	GPPGGLQEFN	FIVPTGKTGL	IIGKGGETIK
SISQQSGARI	ELQRNPPPNA	DPNMKLFTIR	GTPQQIDYAR	QLIEEKIGGP
VNPLGPPVPH	GPHGVPGPHG	PPGPPGPGTP	MGPYNPAPYN	PGPPGPAPHG
PPAPYAPQGW	GNAYPHWQQQ	APPDPAKAGT	DPNSAAWAAY	YAHYYQQQAQ
PPPAAPAGAP	TTTQTNGQGD	QQNPAPAGQV	DYTKAWEEYY	KKMGQAVPAP
TGAPPGGQPD	YSAAWAEYYR	QQAAYYAQTS	PQGMPQHPPA	PQGQ

Funkcija[uredi | uredi izvor]

Ovaj gen kodira protein koji se vezuje za ssDNK, a koji aktivira daleko uzvodni element (FUSE) c-myc i stimulira ekspresiju c-myc u nediferenciranim ćelijama. Regulacija FUSE-a pomoću FUBP-a se događa jednolančanim vezivanjem FUBP-a za nekodirajući lanac. Pokazalo se da ovaj protein funkcionira kao ATP-ovisna DNK helikaza.^[6]

Interakcije[uredi | uredi izvor]

Pokazalo se da protein 1 koji vezuje elemente daleko uzvodno reaguje sa MAPK14^[8] i SMN1.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162613 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028034 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (april 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
^ ^a ^b "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
^ "UniProt, Q96AE4" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)
^ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (juli 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. United States. 34 (3): 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.
^ Williams, B Y; Hamilton S L; Sarkar H K (mart 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. NETHERLANDS. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.

Dopunska literatura[uredi | uredi izvor]

Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. PMID 10734235. S2CID 28330997.
Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC 113884. PMID 11071946.
Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC 29729. PMID 11222755.
Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi:10.1016/S0092-8674(01)00223-9. PMID 11239393.
Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. Bibcode:2002Natur.415.1051B. doi:10.1038/4151051a. PMID 11875576. S2CID 4401103.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. S2CID 41006480.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID 15502847. S2CID 28956216.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC 1462968. PMID 16628215.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162613 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028034 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8125259-5] Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (april 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.

[entrez-6] "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".

[UniProt-7] "UniProt, Q96AE4" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid12819782-8] Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (juli 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. United States. 34 (3): 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.

[pmid10734235-9] Williams, B Y; Hamilton S L; Sarkar H K (mart 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. NETHERLANDS. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.

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