HES2

HES2
Identifikatori
Aliasi	HES2
Vanjski ID-jevi	OMIM: 609970 MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	6,424,670 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	152,246,926 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • double-stranded DNA binding; • transcription factor binding; • protein dimerization activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Ćelijska komponenta	• jedro;
Biološki proces	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • somitogenesis; • Notch signaling pathway; • Ćelijska diferencijacija; • regulation of neurogenesis; • anterior/posterior pattern specification;
	Izvori:Amigo / QuickGO
Ortolozi
	54626
	15206
	ENSG00000069812
	ENSMUSG00000028940
	Q9Y543
	O54792
	NM_019089
	NM_001301805; NM_008236
	NP_061962
	NP_001288734; NP_032262
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transkripcijski faktor 2 Hes porodice bHLH jest protein koji je kod ljudi kodiran genom HES2 sa hromosoma 1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 173 aminokiselina, a molekulska težina. 18.470 Da^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGLPRRAGDA	AELRKSLKPL	LEKRRRARIN	QSLSQLKGLI	LPLLGRENSN
CSKLEKADVL	EMTVRFLQEL	PASSWPTAAP	LPCDSYREGY	SACVARLARV
LPACRVLEPA	VSARLLEHLW	RRAASATLDG	GRAGDSSGPS	APAPAPASAP
EPASAPVPSP	PSPPCGPGLW	RPW

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hes family bHLH transcription factor 2".
^ "UniProt, Q9Y543" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (april 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
Katoh M, Katoh M (august 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
Katoh M, Katoh M (august 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.

Vanjski linkovi[uredi | uredi izvor]

Šablon:Transkripcijski faktori i unutarćelijski receptori

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Hes family bHLH transcription factor 2".

[UniProt-6] "UniProt, Q9Y543" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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